ArticleBiomedical physics & engineering express2018
Pulsed Terahertz Reflection Imaging of tumors in a spontaneous model of breast cancer.
Article in Biomedical physics & engineering express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Terahertz Imaging for Breast Cancer Detection in Animal Models: A Literature Review with Narrative Synthesis.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Review
- Polarimetry terahertz imaging of human breast cancer surgical specimens.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Review
- Performance Analysis of an Aperture-Coupled THz Antenna for Diagnosing Breast Cancer.Micromachines · 2023Article
- Development of Terahertz Imaging Markers for Pancreatic Ductal Adenocarcinoma using MaximumACS omega · 2023Article
- Advances in terahertz technology for cancer detection applications.Optical and quantum electronics · 2023Review
- Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis.Diagnostics (Basel, Switzerland) · 2022Article
- Terahertz Imaging for Breast Cancer Detection.Sensors (Basel, Switzerland) · 2021Review
- Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors.Journal of visualized experiments : JoVE · 2020Article
- Breast Cancer Detection with Low-dimension Ordered Orthogonal Projection in Terahertz Imaging.IEEE transactions on terahertz science and technology · 2020Article
- Terahertz Imaging and Spectroscopy in Cancer Diagnostics: A Technical Review.BME frontiers · 2020Review
- Terahertz tomographic imaging of freshly excised human breast tissues.Journal of medical imaging (Bellingham, Wash.) · 2019Article
- Cancer detection in excised breast tumors using terahertz imaging and spectroscopy.Biomedical spectroscopy and imaging · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We report the use of reflection-mode terahertz (THz) imaging in a transgenic mouse model of breast cancer. Unlike tumor xenografts that are grown from established cell lines, these tumors were spontaneously generated in the mammary fat pad of mice, and are a better representation of human breast cancer. THz imaging results from 7 tumors that recapitulate the compartmental complexity of breast cancer are presented here. Imaging was first performed on freshly excised tumors within an hour of excision and then repeated after fixation with formalin and paraffin. These THz images were then compared with histopathology to determine reflection-mode signals from specific regions within tumor. Our results demonstrate that the THz signal was consistently higher in cancerous tissue compared with fat, muscle, and fibrous tissue. Almost all tumors presented in this work demonstrated advanced stages where cancer infiltrated other tissues like fat and fibrous stroma. As the first known THz investigation in a transgenic model, these results hold promise for THz imaging at different stages of breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.