Evidence map›Paper›PMID 31275600›Full record

ArticleObesity science & practice2019

Exercise training alters lipoprotein particles independent of brown adipose tissue metabolic activity.

P Motiani, J Teuho, T Saari, K A Virtanen, S M Honkala, R J Middelbeek, L J Goodyear, O Eskola, J Andersson, E Löyttyniemi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Obesity science & practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

P MotianiTurku PET Centre University of Turku Turku Finland.ORCID https://orcid.org/0000-0002-2876-1851
J TeuhoTurku PET Centre University of Turku Turku Finland.ORCID https://orcid.org/0000-0001-9401-0725
T SaariTurku PET Centre University of Turku Turku Finland.ORCID https://orcid.org/0000-0002-3212-6906
K A VirtanenTurku PET Centre University of Turku Turku Finland.
S M HonkalaTurku PET Centre University of Turku Turku Finland.ORCID https://orcid.org/0000-0001-9299-752X
R J MiddelbeekSection on Integrative Physiology and Metabolism Joslin Diabetes Center, Harvard Medical School Boston MA USA.ORCID https://orcid.org/0000-0003-3862-8082
L J GoodyearSection on Integrative Physiology and Metabolism Joslin Diabetes Center, Harvard Medical School Boston MA USA.
O EskolaTurku PET Centre University of Turku Turku Finland.ORCID https://orcid.org/0000-0002-9874-5662
J AnderssonSection of Radiology, Department of Surgical Sciences Uppsala University Uppsala Sweden.
E LöyttyniemiDepartment of Biostatistics University of Turku Turku Finland.
J C HannukainenTurku PET Centre University of Turku Turku Finland.ORCID https://orcid.org/0000-0002-8692-4049
P NuutilaTurku PET Centre University of Turku Turku Finland.ORCID https://orcid.org/0000-0001-9597-338X
University of Turku · FIJoslin Diabetes Center · USUppsala University · SE

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI AMY JO WAGERS · 1986 to 2026
$50.5M
Novel Mechanisms of Exercise Training Effects on Glucose HomeostasisR01DK099511 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 2014 to 2026
$6.5M
Exercise Regulation of Human Adipose TissueR01DK112283 · NIDDK · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 2016 to 2018
$1.2M
Mechanisms of exercise effects in obese humans: sex-specific regulation of novel adipose tissue functionK23DK114550 · NIDDK · JOSLIN DIABETES CENTER · PI MIDDELBEEK, ROELAND J · 2018 to 2022
$956k
NIDDK NIH HHS K23 DK114550NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK099511NIDDK NIH HHS R01 DK112283
6 · The paper itself

Abstract

introductionNew strategies for weight loss and weight maintenance in humans are needed. Human brown adipose tissue (BAT) can stimulate energy expenditure and may be a potential therapeutic target for obesity and type 2 diabetes. However, whether exercise training is an efficient stimulus to activate and recruit BAT remains to be explored. This study aimed to evaluate whether regular exercise training affects cold-stimulated BAT metabolism and, if so, whether this was associated with changes in plasma metabolites.

methodsHealthy sedentary men (

resultsCold exposure increased supraclavicular BAT GU by threefold (

conclusionsAlthough exercise training plays an important role for metabolic health, its beneficial effects on whole body metabolism through physiological adaptations seem to be independent of BAT activation in young, sedentary men.

Indexed as

Brown adipose tissueexercise trainingglucose uptakenor‐epinephrinepositron emission tomography

Identifiers

PMID31275600
PMCPMC6587322
OpenAlexW2912390602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.