ArticleBMJ open diabetes research & care2019
Neuropathic pain is not associated with serum vitamin D but is associated with female gender in patients with type 2 diabetes mellitus.
Article in BMJ open diabetes research & care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Altered blood-based biomarkers in carpal tunnel syndrome. A systematic review and meta-analysis.Musculoskeletal science & practice · 2026Pooled it
- Association Between Serum 25-Hydroxyvitamin D Levels and Neuropathic Pain Features in Adults Presenting with Musculoskeletal Pain: A Cross-Sectional Study.Metabolites · 2026Article
- The Role of Vitamin D in Neuropathic Pain: Biological Mechanisms and Clinical Relevance.International journal of molecular sciences · 2026Review
- Review
- Genetic Evidence Indicates that Serum Micronutrient Levels Mediate the Causal Relationships Between Immune Cells and Neuropathic Pain: A Mediation Mendelian Randomization Study.Molecular neurobiology · 2025Article
- Sex-Specific Association Between Vitamin D Insufficiency and Burning Pain in Herpetic Neuralgia: A Prospective Cohort Study.Journal of pain research · 2025Article
- The Economic Burden of Patients with Diabetic Peripheral Neuropathic Pain Based on a Real-World Study in China.ClinicoEconomics and outcomes research : CEOR · 2025Article
- How does diabetic peripheral neuropathy impact patients' burden of illness and the economy? A retrospective study in Beijing, China.Frontiers in public health · 2023Observational
- Correlation Between Fibrinogen/Albumin and Diabetic Peripheral Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Neuropathic Pain and its Relationship With Fibromyalgia, Vitamin D Status and Medication Use in Patients With Ankylosing Spondylitis.Journal of rheumatic diseases · 2021Article
- Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study.Cardiovascular diabetology · 2021Observational
- Association of time in range, as assessed by continuous glucose monitoring, with painful diabetic polyneuropathy.Journal of diabetes investigation · 2021Article
- Severe Vitamin D Deficiency Is Associated With Increased Expression of Inflammatory Cytokines in Painful Diabetic Peripheral Neuropathy.Frontiers in nutrition · 2021Article
- The impact of vitamin D supplementation on peripheral neuropathy in a sample of Egyptian prediabetic individuals.F1000Research · 2021Article
- Association Between Vitamin D Status and Diabetic Complications in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Hunan China.Frontiers in endocrinology · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Neuropathic pain is a common complication of diabetes mellitus (DM). Patients may complain of several neuropathic symptoms including impaired peripheral sensation, numbness, tingling, burning, and pain. Because these symptoms may cross with symptoms of vitamin D deficiency, we hypothesized that neuropathic pain and vitamin D deficiency may be associated in patients with type 2 DM. Research design and methods: This is a cross-sectional study that involved 239 participants with type 2 DM. Neuropathic pain was assessed using PainDETECT questionnaire. Serum 25-hydroxyvitamin D was measured by the electrochemiluminescence immunoassay, fasting blood glucose was measured by the hexokinase method and hemoglobin A1c was measured by the turbidimetric inhibition immunoassay. Results: The prevalence of neuropathic pain among type 2 DM participants was 26.8%. Vitamin D deficiency was reported in 67.8% of type 2 DM participants. The neuropathy score for females was significantly higher than that for males (p<0.01). There was no significant difference in serum vitamin D between type 2 DM participants according to their gender and according to their neuropathy status (p>0.05). Ordinal logistic regression analysis has shown that female gender was the only significant predictor of neuropathic pain among type 2 DM participants (p<0.01 with an OR (95% CI) of 2.45 (1.29 to 4.67)). Conclusions: Neuropathic pain was not associated with serum vitamin D but was associated with female gender in type 2 DM. Because our results were not consistent with other studies that used different neuropathy assessment tools, we suggest that further research should be conducted to check the validity of these tools in identifying subjects with neuropathy.
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