Evidence map›Paper›PMID 31275502›Full record

ArticlePharmacy practice

Investigating the efficacy of an interactive warning for use in labeling strategies used by us pharmacies.

Jiyon Lee, Moslem Ladoni, James Richardson, Raghav P Sundar, Laura Bix

Abstract read
In one paragraph

Article in Pharmacy practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiyon LeeSchool of Packaging, Michigan State University. East Lansing, MI (United States). leejiyo4@msu.edu.ORCID 0000-0003-2269-8916
Moslem LadoniStatistical Consulting Center, CANR Biometry Group, Michigan State University. East Lansing, MI (United States). moslemladoni@gmail.com.ORCID 0000-0003-1095-4812
James RichardsonSchool of Packaging, Michigan State University, East Lansing, MI (United States). Richardsonjar@yahoo.com.ORCID 0000-0001-9118-8771
Raghav P SundarSchool of Packaging, Michigan State University, East Lansing, MI (United States). raghavprashant.sunda@cardinalhealth.com.ORCID 0000-0001-7565-4269
Laura BixSchool of Packaging, Michigan State University, East Lansing, MI (United States). bixlaura@msu.edu.ORCID 0000-0002-5779-7474

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnited States pharmacies repackage medications into multi-dose vials, enabling customized dosing for prescription drugs. Investment in infrastructure has made this the predominant approach to packaging for US prescriptions. Although recent changes to labeling now discourage the use of auxiliary labels (small stickers highlighting information germane to the safe and effective use), they are still allowed by USP<17>, provided their use comes from an evidence-based perspective.

objectivesEvaluate how 'interactive,' placements of auxiliary labels (placement requiring physical manipulation of the warning to accomplish a task (e.g. opening)) garner attention as compared to those placed vertically or horizontally.

methodsNinety-six participants were eye tracked while opening three prescription vials (each with an auxiliary warning label with a different placement: vertical, horizontal and interactive). Recall and recognition were tested subsequently. Linear mixed models were used to analyze the continuous variables while the binary response variables were analyzed using generalized linear mixed models. The effect of auxiliary labels was fitted as a fixed effect and the subject-to-subject variation was considered as a random effect in the model. Participants' age, health literacy and sex were added to the models if their effect was statistically significant at alpha=0.05.

resultsThe placement of the warnings significantly impacted the time spent viewing the information they contained at alpha=0.05; people spent significantly longer on interactive placements (0.96; SD 0.13 seconds) than either, horizontal placements (0.27; SD 0.037 seconds) or those placed vertically (0.18 seconds; SD 0.035). Participants were equally as likely to see information presented in an interactive placement (90%; SD 3.8) or horizontal placement (78%; SD 05.5) but less likely to view warnings placed vertically (60%; SD 6.9). Free recall responses also supported the use of interactive placement (62%; SD 6.8 recall) as compared to horizontal placements which were 29%; SD 3.0 and 20%; SD 6.0 for vertical placements.

conclusionsData provides evidence which suggests that interactive and horizontal placements out-perform auxiliary labels placed vertically on prescription vials with regard to garnering patient attention.

Indexed as

AttentionCross-Sectional StudiesDrug PackagingFixationHealth LiteracyMental RecallOcularPharmaciesPrescription DrugsProduct LabelingUnited States

Identifiers

PMID31275502
PMCPMC6594438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.