Evidence map›Paper›PMID 31275454›Full record

ArticleDisease markers2019

Expression and Clinical Relevance of SOX9 in Gastric Cancer.

Patrícia Mesquita, Ana F Freire, Nair Lopes, Rosa Gomes, Daniela Azevedo, Rita Barros, Bruno Pereira, Bruno Cavadas, Helena Pópulo, Paula Boaventura and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. SOX9: an important factor in regulating breast cancer.European journal of medical research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Patrícia Mesquitai3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Ana F Freirei3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Nair Lopesi3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Rosa GomesServiço de Oncologia Médica do Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
Daniela AzevedoServiço de Oncologia Médica do Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
Rita Barrosi3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Bruno Pereirai3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Bruno Cavadasi3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Helena Pópuloi3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Paula Boaventurai3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Leonor Davidi3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.ORCID 0000-0003-4207-9258
Luísa Pereirai3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Raquel Almeidai3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-5622-1633
Universidade do Porto · PTUnidade Local de Saúde de Trás-os-Montes e Alto Douro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer is one of the most frequent tumours and the third leading cause of cancer-related death worldwide. The investigation of new biomarkers that can predict patient outcome more accurately and allow better treatment and follow-up decisions is of crucial importance. SOX9 (sex-determining region Y (SRY)-box 9) is a regulator of cell fate decisions in embryogenesis and adulthood. Here, we sought to ascertain the relevance of SOX9 transcription factor as a prognostic marker in gastric cancer. SOX9 expression was analyzed by immunohistochemistry in 333 gastric adenocarcinoma cases, and its association with clinicopathological and follow-up data was evaluated. SOX9 nuclear expression was absent in 17% of gastric cancer cases and predicted worse disease-free survival (

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorFemaleHumansMaleMiddle AgedSOX9 Transcription FactorStomach NeoplasmsBiomarkers, TumorSOX9 protein, humanSOX9 Transcription Factor

Identifiers

PMID31275454
PMCPMC6589301
OpenAlexW2946945400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.