Evidence map›Paper›PMID 31275449›Full record

SynthesisDisease markers2019

The Prognostic Role of Klotho in Patients with Chronic Kidney Disease: A Systematic Review and Meta-analysis.

Qi-Feng Liu, Li-Xia Yu, Jian-Hua Feng, Qiang Sun, Sha-Sha Li, Jian-Ming Ye

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Sex-specific modulation of renal epigenetic and injury markers in aging kidney.American journal of physiology. Renal physiology · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Role of Klotho Protein in Neuropsychiatric Disorders: A Narrative Review.Indian journal of clinical biochemistry : IJCB · 2023
    Review
  12. Structural and Functional Changes in Aging Kidneys.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qi-Feng LiuDepartment of Nephrology, Kunshan First People's Hospital Affiliated to Jiangsu University, 91 Qianjin West Road, Kunshan, Jiangsu 215300, China.
Li-Xia YuDepartment of Nephrology, Kunshan First People's Hospital Affiliated to Jiangsu University, 91 Qianjin West Road, Kunshan, Jiangsu 215300, China.
Jian-Hua FengDepartment of Nephrology, Kunshan First People's Hospital Affiliated to Jiangsu University, 91 Qianjin West Road, Kunshan, Jiangsu 215300, China.
Qiang SunDepartment of Nephrology, Kunshan First People's Hospital Affiliated to Jiangsu University, 91 Qianjin West Road, Kunshan, Jiangsu 215300, China.
Sha-Sha LiClinical Research & Lab Centre, Kunshan First People's Hospital Affiliated to Jiangsu University, 91 Qianjin West Road, Kunshan, Jiangsu 215300, China.ORCID 0000-0001-9177-8173
Jian-Ming YeDepartment of Nephrology, Kunshan First People's Hospital Affiliated to Jiangsu University, 91 Qianjin West Road, Kunshan, Jiangsu 215300, China.ORCID 0000-0002-4802-4365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe prognostic role of Klotho in patients with chronic kidney disease is still controversial. Therefore, we performed this meta-analysis to assess the relationship between the low sKlotho level and the risk of adverse kidney outcomes. MATERIALS AND

methodsWe systematically searched medical databases, such as PubMed, Embase, and the Cochrane Library, for eligible publications regarding the relationship between the low sKlotho level and risk of adverse kidney outcomes. The quality of included studies was assessed by using the Newcastle-Ottawa Scale. Combined hazard ratios (HRs) and its 95% confidence intervals (CIs) were calculated using a random- or fixed-effect model. Subgroup analysis was conducted with stratification by age, estimated glomerular filtration rate (eGFR), follow-up interval, region, and study quality. All data was analyzed by RevMan 5.3 analysis software.

resultsEight cohort studies with 3586 participants from 3818 studies were included in our final analysis. Levels of sKlotho were significantly correlated with the eGFR, with a summary correlation coefficient

conclusionLevels of sKlotho are positively correlated with the eGFR, and low sKlotho levels are significantly associated with an increased risk of poor kidney outcomes. Therefore, sKlotho could be used as a novel biomarker for early diagnosis and prognostic assessment for patients with chronic kidney disease. Studies with a larger sample size and longer follow-up period are warranted to validate our results.

Indexed as

AdultAgedAged, 80 and overBiomarkersGlomerular Filtration RateGlucuronidaseHumansKlotho ProteinsMiddle AgedRenal Insufficiency, ChronicBiomarkersGlucuronidaseKlotho Proteins

Identifiers

PMID31275449
PMCPMC6589248

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.