Evidence map›Paper›PMID 31275447›Full record

Observational studyDisease markers2019

Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders.

Mattia Bellan, Ailia Giubertoni, Cristina Piccinino, Arnaldo Dimagli, Federico Grimoldi, Maurizio Sguazzotti, Michela Emma Burlone, Carlo Smirne, Daniele Sola, Paolo Marino and 2 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Mattia BellanDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.ORCID 0000-0003-1488-8736
Ailia GiubertoniDivision of Cardiology, "Maggiore della Carità" Hospital, Corso Mazzini 18, 28100 Novara, Italy.
Cristina PiccininoDivision of Cardiology, "Maggiore della Carità" Hospital, Corso Mazzini 18, 28100 Novara, Italy.
Arnaldo DimagliDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.
Federico GrimoldiDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.
Maurizio SguazzottiDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.
Michela Emma BurloneDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.
Carlo SmirneDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.ORCID 0000-0002-3338-5416
Daniele SolaDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.
Paolo MarinoDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.ORCID 0000-0002-8192-412X
Mario PirisiDepartment of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.ORCID 0000-0001-9740-0155
Pier Paolo SainaghiDivision of Internal Medicine, Immunorheumatology Unit, "Maggiore della Carità" Hospital, Corso Mazzini 18, 28100 Novara, Italy.ORCID 0000-0001-8322-9158
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION/

objectiveIn the present paper, we aimed to test the value of the red cell distribution width (RDW) coefficient of variation as a candidate biomarker for pulmonary arterial hypertension (PAH) in patients with connective tissue disorders (CTD), correlating it with the degree of cardiopulmonary impairment in these patients.

methodsThe study population included

resultsTwenty out of 141 CTD patients (14%) received a diagnosis of PAH. In comparison to those without PAH, CTD patients with PAH displayed a larger RDW (14.9% (13.5-17.2) vs. 13.8% (13.1-15.0);

conclusionRDW is a promising candidate biomarker for the screening and the prognostic stratification of PAH in CTD patients.

Indexed as

AgedBiomarkersConnective Tissue DiseasesErythrocyte CountFemaleHumansHypertension, PulmonaryMaleMiddle AgedPlatelet CountBiomarkers

Identifiers

PMID31275447
PMCPMC6589198
OpenAlexW2947746796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.