ArticleEvidence-based complementary and alternative medicine : eCAM2019
Acupuncture Regulating Gut Microbiota in Abdominal Obese Rats Induced by High-Fat Diet.
Article in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- The effects of laser acupuncture on metabolic syndrome in obese postmenopausal women: a randomized controlled study.Lasers in medical science · 2024Trial
- Acupuncture of polycystic ovary syndrome: delving into bile acid metabolism.Chinese medicine · 2026Article
- Acupuncture modulates the microbiota-gut-brain axis to treat irritable bowel syndrome: a mechanistic exploration.Frontiers in neuroscience · 2026Review
- Changes in Gut Microbiome Following Acupuncture and Moxibustion in Patients With Parkinson Disease: Protocol for a Single-Group, Prospective, Observational Study.JMIR research protocols · 2025Article
- Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats.Diabetology & metabolic syndrome · 2025Article
- Acupuncture and nutritional parallels in obesity: a narrative review of multi-pathway modulation of the microbiota-gut-brain axis.Frontiers in nutrition · 2025Review
- Article
- Acupuncture and moxibustion intervention in functional dyspepsia: Gastric and duodenal regulation.Heliyon · 2024Review
- Acupuncture influences multiple diseases by regulating gut microbiota.Frontiers in cellular and infection microbiology · 2024Review
- Electroacupuncture regulates gut microbiota to reduce depressive-like behavior in rats.Frontiers in microbiology · 2024Article
- Efficacy of acupuncture in patients with mild Alzheimer's disease and its impact on gut microbiota: Study protocol for a randomized sham-controlled trial.Frontiers in medicine · 2023Article
- Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role.Frontiers in neuroscience · 2023Review
- Acupuncture as multi-targeted therapy for the multifactorial disease obesity: a complex neuro-endocrine-immune interplay.Frontiers in endocrinology · 2023Review
- Electroacupuncture reduces blood glucose by regulating intestinal flora in type 2 diabetic mice.Journal of diabetes · 2022Article
- Three-dimensional visualization of electroacupuncture-induced activation of brown adipose tissue via sympathetic innervation in PCOS rats.Chinese medicine · 2022Article
- The next generation beneficial actions of novel probiotics as potential therapeutic targets and prediction tool for metabolic diseases.Journal of food and drug analysis · 2022Review
- Changes of local microenvironment and systemic immunity after acupuncture stimulation during inflammation: A literature review of animal studies.Frontiers in neurology · 2022Review
- Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease.Mediators of inflammation · 2022Review
- Article
- Preventive electroacupuncture ameliorates D-galactose-induced Alzheimer's disease-like inflammation and memory deficits, probably via modulating the microbiota-gut-brain axis.Iranian journal of basic medical sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effects of acupuncture on metabolic health and gut microbiota dysbiosis in diet-induced abdominal obese model. MATERIALS AND
methodsMale Sprague-Dawley rats were randomly distributed into normal chow diet (NCD) group and high-fat diet (HFD) group. After 12 weeks of HFD feeding, an abdominal obese rat model was established. The abdominal obese rats were further assigned to acupuncture group (n=7) and nontreated HFD group (n=7). Acupuncture was applied to bilateral GB 26 of rats for 8 weeks. Subsequently, the body weight, waist circumference (WC), visceral fat mass, and liver weight were measured weekly in all rats. Metabolic parameters such as total cholesterol, triglyceride, alanine aminotransferase, aspartate transaminase, and blood glucose were measured by an automatic biochemical analyzer. The serum levels of insulin (INS) were determined using Rat INS ELISA Kit. Analysis of gut microbiota was carried out by 16S rRNA gene sequencing.
resultsAcupuncture decreased the body weight, WC, and visceral adipose tissues of HFD-induced abdominal obese rats. In addition, insulin sensitivity, glucose homeostasis, and lipid metabolism were improved by this treatment. Furthermore, electroacupuncture effectively modified the composition of gut microbiota, mainly via decreasing Firmicutes/Bacteroidetes ratio and increasing Prevotella_9 abundance.
conclusionsElectroacupuncture can ameliorate abdominal obesity and prevent metabolic disorders in HFD-induced abdominal obese rats, via the modulation of gut microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.