Evidence map›Paper›PMID 31275329›Full record

ArticleFrontiers in immunology2019

Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models.

Hideyuki Ujiie, Norihiro Yoshimoto, Ken Natsuga, Ken Muramatsu, Hiroaki Iwata, Wataru Nishie, Hiroshi Shimizu

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05235087 (Bovine Atelocollagen Skin Sensitization Test), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05235087 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

Bovine Atelocollagen Skin Sensitization Test

TypeinterventionalSponsorAscentX Medical, Inc.Ran2023 to 2023Enrolled0ConditionsHealthyArmsBovine atelocollagen intradermal injection
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Bullous pemphigoid.Nature reviews. Disease primers · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Understanding CD4Frontiers in immunology · 2023
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hideyuki UjiieDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Norihiro YoshimotoDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Ken NatsugaDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Ken MuramatsuDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Hiroaki IwataDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Wataru NishieDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Hiroshi ShimizuDepartment of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Hokkaido University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bullous pemphigoid (BP), the most common autoimmune blistering disease, is induced by autoantibodies to type XVII collagen (COL17). Previous studies demonstrated that COL17 harbors several epitopes targeted by autoreactive T and B cells and that the target epitopes change sequentially during the disease course. To elucidate the details of the humoral immune response to COL17, we used an active BP mouse model in which BP is induced by the adoptive transfer of spleen cells from wild-type mice immunized with human COL17-expressing skin grafting to immunodeficient COL17-humanized (Rag-2

Indexed as

AutoimmunityAnimalsAutoantibodiesAutoantigensCD40 AntigensCD40 LigandCollagen Type XVIIDisease Models, AnimalDisease SusceptibilityEpitopesHumansImmunomodulationMiceMice, KnockoutMice, TransgenicModels, BiologicalAutoantibodiesAutoantigensCD40 AntigensCD40 LigandCollagen Type XVIIEpitopesNon-Fibrillar Collagensactive mouse modelautoantibodyautoimmunityBP180BP230CD40 ligandCOL17NC16A domain

Identifiers

PMID31275329
PMCPMC6593113
OpenAlexW2952865104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.