Evidence map›Paper›PMID 31275315›Full record

ArticleFrontiers in immunology2019

MicroRNA-155 Controls T Helper Cell Activation During Viral Infection.

Eliana Goncalves-Alves, Victoria Saferding, Christopher Schliehe, Robert Benson, Mariola Kurowska-Stolarska, Julia Stefanie Brunner, Antonia Puchner, Bruno K Podesser, Josef S Smolen, Kurt Redlich and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Frontiers in immunology · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Extracellular Vesicle-Related Thrombosis in Viral Infection.International journal of general medicine · 2020
    Review
  17. Article
  18. The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 disease.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Eliana Goncalves-AlvesDepartment of Rheumatology, Medical University Vienna, Vienna, Austria.
Victoria SaferdingDepartment of Rheumatology, Medical University Vienna, Vienna, Austria.
Christopher SchlieheCeMM - Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Robert BensonInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Mariola Kurowska-StolarskaInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Julia Stefanie BrunnerInstitute for Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria.
Antonia PuchnerDepartment of Rheumatology, Medical University Vienna, Vienna, Austria.
Bruno K PodesserDepartment of Biomedical Research, Medical University of Vienna, Vienna, Austria.
Josef S SmolenDepartment of Rheumatology, Medical University Vienna, Vienna, Austria.
Kurt RedlichDepartment of Rheumatology, Medical University Vienna, Vienna, Austria.
Michael BonelliDepartment of Rheumatology, Medical University Vienna, Vienna, Austria.
James BrewerInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Andreas BergthalerCeMM - Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Günter SteinerDepartment of Rheumatology, Medical University Vienna, Vienna, Austria.
Stephan BlümlDepartment of Rheumatology, Medical University Vienna, Vienna, Austria.
Medical University of Vienna · ATUniversity of Glasgow · GBAustrian Academy of Sciences · ATCeMM Research Center for Molecular Medicine · ATChristian Doppler Laboratory for Thermoelectricity · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNA (miR) 155 has been implicated in the regulation of innate and adaptive immunity as well as autoimmune processes. Importantly, it has been shown to regulate several antiviral responses, but its contribution to the immune response against cytopathic viruses such as vesicular stomatitis virus (VSV) infections is not known. Using transgenic/recombinant VSV expressing ovalbumin, we show that miR-155 is crucially involved in regulating the T helper cell response against this virus. Our experiments indicate that miR-155 in CD4

Indexed as

Adoptive TransferAnimalsAntibodies, NeutralizingAntibodies, ViralAntigen-Presenting CellsCell ProliferationCytokinesLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMicroRNAsOvalbuminT-Lymphocytes, Helper-InducerVesicular stomatitis Indiana virusAntibodies, NeutralizingAntibodies, ViralCytokinesMicroRNAsMirn155 microRNA, mouseOvalbuminantiviral immunityAPCsAPC-T cell interactionmicroRNA-155T cell activationT helper cells

Identifiers

PMID31275315
PMCPMC6593301
OpenAlexW2951471037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.