Evidence map›Paper›PMID 31275297›Full record

ArticleFrontiers in immunology2019

Rapid Multiplex Genotyping of 20 HLA-A

Dmitrii S Romaniuk, Anna M Postovskaya, Alexandra A Khmelevskaya, Dmitry B Malko, Grigory A Efimov

Abstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. AScall - Automatic Allele-Specific qPCR Analysis.Frontiers in bioengineering and biotechnology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dmitrii S RomaniukLaboratory for Transplantation Immunology, National Research Center for Hematology, Moscow, Russia.
Anna M PostovskayaLaboratory for Transplantation Immunology, National Research Center for Hematology, Moscow, Russia.
Alexandra A KhmelevskayaLaboratory for Transplantation Immunology, National Research Center for Hematology, Moscow, Russia.
Dmitry B MalkoLaboratory for Transplantation Immunology, National Research Center for Hematology, Moscow, Russia.
Grigory A EfimovLaboratory for Transplantation Immunology, National Research Center for Hematology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A subset of MHC-associated self-peptides presented by the recipient's cells and immunologically foreign to the donor can induce an allogeneic immune response after hematopoietic stem cell transplantation (HSCT). These immunogenic peptides originate from the genomic polymorphisms and are known as minor histocompatibility antigens (MiHA). MiHA mismatches trigger the post-transplant immune response, which could manifest in both the deleterious "graft-vs.-host" disease and the beneficial "graft-vs.-leukemia" effect. Importantly, some MiHAs are considered to be promising targets for posttransplant T-cell immunotherapy of hematopoietic malignancies. This creates a demand for a robust and fast approach to genotyping MiHA-encoding polymorphisms. We report a multiplex real-time PCR method for the genotyping of 20 polymorphisms that are encoding HLA-A

Indexed as

AllelesGenomicsGenotypeGraft vs Host DiseaseGraft vs Leukemia EffectHematologic NeoplasmsHematopoietic Stem Cell TransplantationHLA-A AntigensHumansMinor Histocompatibility AntigensT-LymphocytesTransplantation, HomologousHLA-A AntigensMinor Histocompatibility Antigensallele-specific primerAS-PCRAS-qPCRHSCTMiHAminor histocompatibility antigensmultiplex qPCRSNP genotyping

Identifiers

PMID31275297
PMCPMC6593292

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.