Evidence map›Paper›PMID 31275224›Full record

ArticleFrontiers in neurology2019

Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling.

Wenbin Wan, Lan Cao, Bill Kalionis, Padma Murthi, Shijin Xia, Yangtai Guan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

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  14. Pulling back the mitochondria's iron curtain.npj metabolic health and disease · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Wenbin WanDepartment of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lan CaoState Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Bill KalionisDepartment of Maternal-Fetal Medicine, Pregnancy Research Centre, University of Melbourne, Parkville, VIC, Australia.
Padma MurthiDepartment of Obstetrics and Gynecology, University of Melbourne, Parkville, VIC, Australia.
Shijin XiaShanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai, China.
Yangtai GuanDepartment of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
University of Melbourne · AUHuadong Hospital · CNRenji Hospital · CNShanghai Jiao Tong University · CNState Key Laboratory of Medical Neurobiology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron deposition in the brain is an early issue in Alzheimer's disease (AD). However, the pathogenesis of iron-induced pathological changes in AD remains elusive. Insulin resistance in brains is an essential feature of AD. Previous studies determined that insulin resistance is involved in the development of pathologies in AD. Tau pathology is one of most important hallmarks in AD and is associated with the impairment of cognition and clinical grades of the disease. In the present study, we observed that ferrous (Fe

Indexed as

Alzheimer's diseaseinsulin resistanceiron depositionphosphorylationtau

Identifiers

PMID31275224
PMCPMC6593079
OpenAlexW2952790855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.