ArticleFrontiers in neurology2019
Altered Whole-Brain Functional Topological Organization and Cognitive Function in Type 2 Diabetes Mellitus Patients.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging.Frontiers in neurology · 2022Pooled it
- The physiochemical characteristics of Phragmites communis trin polysaccharides andFrontiers in pharmacology · 2026Article
- A study on appetite of overweight/obese patients with type 2 diabetes mellitus based on multimodal magnetic resonance imaging.Frontiers in neuroimaging · 2025Article
- Network efficiency of functional brain connectomes altered in type 2 diabetes patients with and without mild cognitive impairment.Diabetology & metabolic syndrome · 2024Article
- Cognition and motion dysfunction-associated brain functional network disruption in diabetic peripheral neuropathy.Human brain mapping · 2024Article
- Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus.Frontiers in neuroscience · 2024Article
- The Interaction of Glycemia with Anxiety and Depression Is Related to Altered Cerebellar and Cerebral Functional Correlations.Brain sciences · 2023Article
- Regional homogeneity of adolescents with high-functioning autism spectrum disorder and its association with symptom severity.Brain and behavior · 2022Article
- Convolutional Neural Networks for Classification of T2DM Cognitive Impairment Based on Whole Brain Structural Features.Frontiers in neuroscience · 2022Article
- Integrated Prediction Framework for Clinical Scores of Cognitive Functions in ESRD Patients.Computational intelligence and neuroscience · 2022Article
- Prediction value of the genetic risk of type 2 diabetes on the amnestic mild cognitive impairment conversion to Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Aberrant brain functional networks in type 2 diabetes mellitus: A graph theoretical and support-vector machine approach.Frontiers in human neuroscience · 2022Article
- MRI-based machine learning model: A potential modality for predicting cognitive dysfunction in patients with type 2 diabetes mellitus.Frontiers in bioengineering and biotechnology · 2022Article
- Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy.Investigative ophthalmology & visual science · 2021Article
- Right Frontoinsular Cortex: A Potential Imaging Biomarker to Evaluate T2DM-Induced Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Altered Structural and Functional MRI Connectivity in Type 2 Diabetes Mellitus Related Cognitive Impairment: A Review.Frontiers in human neuroscience · 2021Review
- Altered Functional Topological Organization in Type-2 Diabetes Mellitus With and Without Microvascular Complications.Frontiers in neuroscience · 2021Article
- Application of Functional Magnetic Resonance Imaging in the Diagnosis of Parkinson's Disease: A Histogram Analysis.Frontiers in aging neuroscience · 2021Article
- Altered Gray Matter Volume, Functional Connectivity, and Degree Centrality in Early-Onset Type 2 Diabetes Mellitus.Frontiers in neurology · 2021Article
- Aberrant Brain Functional Connectivity Strength and Effective Connectivity in Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2021Article
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11 authors.
Funding
Abstract
Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction and may even progress to dementia. However, the underlying mechanism of altered functional topological organization and cognitive impairments remains unclear. This study explored the topological properties of functional whole brain networks in T2DM patients with graph theoretical analysis using a resting-state functional magnetic resonance imaging (rs-fMRI) technique. Thirty T2DM patients (aged 51.77 ± 1.42 years) and 30 sex-, age-, and education-matched healthy controls (HCs) (aged 48.87 ± 0.98 years) underwent resting-state functional imaging in a 3.0 T MR scanner in addition to detailed neuropsychological and laboratory tests. Then, graph theoretical network analysis was performed to explore the global and nodal topological alterations in the functional whole brain networks of the T2DM patients. Finally, correlation analyses were performed to investigate the relationship between the altered topological parameters, cognitive performances and clinical variables. Compared to HCs, we found that T2DM patients displayed worse performances in general cognitive function and several cognitive domains, including episodic memory, attention and executive function. In addition, T2DM patients showed a higher small-worldness (σ), a higher normalized clustering coefficient (γ) and a higher local efficiency (E
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