Evidence map›Paper›PMID 31275170›Full record

ArticleFrontiers in physiology2019

Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.

Huihui Gao, Hui Wen, Congcong Cao, Daqian Dong, Chenhao Yang, Shengsong Xie, Jin Zhang, Xunbin Huang, Xingxu Huang, Shuiqiao Yuan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Small Non-coding RNAs and Male Infertility.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Review
  5. Sperm abnormality: Differential expression of microRNAs.Journal of assisted reproduction and genetics · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Role of miRNAs in Bovine Oocyte Maturation and Reproductive Regulation.International journal of molecular sciences · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Frontiers in cell and developmental biology · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Huihui GaoCollege of Animal Science and Technology, Northwest A&F University, Yangling, China.
Hui WenInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Congcong CaoInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Daqian DongCollege of Animal Science and Technology, Northwest A&F University, Yangling, China.
Chenhao YangCollege of Animal Science and Technology, Northwest A&F University, Yangling, China.
Shengsong XieKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education and Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, China.
Jin ZhangCollege of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xunbin HuangInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xingxu HuangSchool of Life Sciences and Technology, ShanghaiTech University, Shanghai, China.
Shuiqiao YuanInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wuzi DongCollege of Animal Science and Technology, Northwest A&F University, Yangling, China.
Northwest A&F University · CNHuazhong University of Science and Technology · CNHuazhong Agricultural University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermatogenesis is a complicated process including spermatogonial stem cells self-renewal and differentiates into mature spermatozoa. MicroRNAs (miRNAs) as a class of small non-coding RNAs play a crucial role during the process of spermatogenesis. However, the function of a plenty of miRNAs on spermatogenesis and the potential mechanisms remain largely unknown. Here, we show that genetically conditional overexpressed miR-10a in germ cells caused complete male sterility, characterized by meiotic arrested in germ cells. Analysis of miR-10a overexpression mouse testes reveals that failure of double strand break (DSB) repairs and aberrant spermatogonial differentiation. Furthermore, we identified

Indexed as

meiosismiRNA-10anon-obstructive azoospermiaoverexpression miceRad51spermatogenesis

Identifiers

PMID31275170
PMCPMC6591449
OpenAlexW2952149286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.