Evidence map›Paper›PMID 31275134›Full record

ArticleCase reports in oncology

Diagnosis of Mixed Adenoneuroendocrine Carcinoma (MANEC) after Neoadjuvant Chemotherapy for Pancreatic and Gastric Adenocarcinoma: Two Case Reports and a Review of the Literature.

Ester Oneda, Barbara Liserre, Denise Bianchi, Luigina Rota, Giordano Savelli, Fausto Zorzi, Alberto Zaniboni

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  5. Review
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ester OnedaDepartment of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy.
Barbara LiserreDepartment of Pathology, Fondazione Poliambulanza, Brescia, Italy.
Denise BianchiDepartment of Pathology, Fondazione Poliambulanza, Brescia, Italy.
Luigina RotaDepartment of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy.
Giordano SavelliDepartment of Nuclear Medicine, Fondazione Poliambulanza, Brescia, Italy.
Fausto ZorziDepartment of Pathology, Fondazione Poliambulanza, Brescia, Italy.
Alberto ZaniboniDepartment of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract involving both epithelial and neuroendocrine (NE) components, each of which represents at least 30% of the tumor. Because of the low frequency of this histotype, only a few cases have been described. In this report we discuss two cases treated with neoadjuvant chemotherapy: a pancreatic adenocarcinoma and a gastric adenocarcinoma. The histopathological specimens examined after surgery showed an additional NE component with a possible indication of the MANEC histotype. We hypothesize two possible explanations: tumor NE cells are more chemo-resistant than adenocarcinoma cells, and cytotoxic injury induces NE differentiation in tumor cells. The clinical significance and prognostic value of endocrine differentiation, however, remain controversial issues.

Indexed as

Mixed adenoneuroendocrine carcinomaNeoadjuvant chemotherapyNeuroendocrine differentiation

Identifiers

PMID31275134
PMCPMC6600038

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.