ArticleJournal of food science and technology2019
β-Carotene solid dispersion prepared by hot-melt technology improves its solubility in water.
Article in Journal of food science and technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Solid Dispersions as a Tool for Innovation in the Food Industry: A Path From Pharma to Food.Journal of food science · 2026Review
- Amorphous Lycopene-PVP K30 Dispersions Prepared by Ball Milling: Improved Solubility and Antioxidant Activity.Polymers · 2025Article
- Regulation of Intestinal Barrier Function and Gut Microbiota by Hot Melt Extrusion-Drug Delivery System-Prepared Mulberry Anthocyanin in an Inflammatory Bowel Disease Model.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Convective drying ofHeliyon · 2024Article
- Effect of hot-melt extrudedHeliyon · 2024Article
- Formulation Approaches to Crystalline Status Modification for Carotenoids: Impacts on Dissolution, Stability, Bioavailability, and Bioactivities.Pharmaceutics · 2023Review
- Hot-Melt Extrusion Enhances Antioxidant Effects of Mulberry on Probiotics and Pathogenic Microorganisms.Antioxidants (Basel, Switzerland) · 2022Article
- Proximate, Elemental, and Functional Properties of Novel Solid Dispersions ofMolecules (Basel, Switzerland) · 2022Article
- Physicochemical and Biochemical Evaluation of Amorphous Solid Dispersion of Naringenin Prepared Using Hot-Melt Extrusion.Frontiers in nutrition · 2022Article
- Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion.Journal of food science and technology · 2022Article
- Naringenin nanocrystals for improving anti-rheumatoid arthritis activity.Asian journal of pharmaceutical sciences · 2021Article
- Article
- Carotenoids in Cancer Apoptosis-The RoadCancers · 2020Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-Carotene is a member of the carotenoid family and is a red-orange pigment abundantly present in many vegetables and fruits. As an antioxidant, it eliminates excessive reactive oxygen species generated in the body. Accordingly, it has potential to be used in the pharmaceutical, food, and cosmetic industries. β-Carotene has a very low water solubility and low bioavailability; thus, there is a need to develop techniques to overcome these issues. In this study, we aimed to enhance the water solubility of β-carotene by using hot-melt technology, a type of solid dispersions technology. When preparing β-carotene solid dispersion using this method, suitable conditions for the emulsifiers and mixing ratios were investigated using water solubility as an index. Setting the weight ratio of β-carotene:polyvinylpyrrolidone:sucrose fatty acid ester to 10%:70%:20% resulted in the poorly-water soluble β-carotene showing improved water solubility (120 μg/mL). The physicochemical properties of the optimized β-carotene solid dispersion were analyzed using field emission scanning electron microscopy, differential scanning calorimetry, and powder X-ray diffraction. The solid dispersion was found to have an amorphous structure. The improved solubility observed for β-carotene in the solid dispersions developed in this work may make these dispersions useful as additives in foods or in nutraceutical formulations.
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