Evidence map›Paper›PMID 31274788›Full record

ArticleJournal of the Chinese Medical Association : JCMA2019

Genetic polymorphisms of ARID5B rs7089424 and rs10994982 are associated with B-lineage ALL susceptibility in Chinese pediatric population.

Ran Tao, Yu-Jie Liu, Li-Fang Liu, Wei Li, Yun Zhao, Hua-Mei Li, Xiao-Lian Yi, Zheng-Yan Zhao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Chinese Medical Association : JCMA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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  4. ARID5B rs7089424 and rs10994982 and association with B-lineage ALL susceptibility.Journal of the Chinese Medical Association : JCMA · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ran TaoLaboratory Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yu-Jie LiuLaboratory Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Li-Fang LiuLaboratory Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wei LiLaboratory Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yun ZhaoLaboratory Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hua-Mei LiLaboratory Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiao-Lian YiDepartment of Pediatrics, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Zheng-Yan ZhaoLaboratory Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Children's Hospital of Zhejiang University · CNAffiliated Hospital of Hangzhou Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral ARID5B single nucleotide polymorphisms (SNPs) were confirmed to be significantly associated with the susceptibility of childhood acute lymphoblastic leukemia (ALL) based on Caucasian populations in previous studies. Similar investigations in Asian populations were less. The aim of this study is to explore the relationship between ARID5B SNPs rs7089424, rs10994982, and the risk of ALL in Chinese pediatric population.

methodsA total of 190 pediatric ALL patients and 270 controls were enrolled in this study. PCR amplification combined with mass spectrometry were used to evaluate the genotypes of ARID5B rs7089424 and rs10994982. χ test was used in allele frequencies and genotype distributions of the SNPs for analyzing statistical differences between patients and controls.

resultsThere were significant differences in the risk allele frequencies of ARID5B rs7089424 and rs10994982 between B-lineage ALL (B-ALL) patients and controls (rs7089424, G allele: p = 0.001; rs10994982, A allele: p = 0.000). The genotype distributions of ARID5B rs7089424 and rs10994982 were also statistically different in B-ALL patients compared with controls (rs7089424, p = 0.004; rs10994982, p = 0.001). Further analyzing the relevance of ARID5B rs7089424 and rs10994982 genotypes to clinical risk classification of ALL showed GG genotype of rs7089424 and AA genotype of rs10994982 were strikingly correlated with the medium-risk and low-risk groups of B-ALL. Finally, GG and GT genotypes of rs7089424 and AA genotype of rs10994982 seemed to be responsible for the hyperdiploid subtype susceptibility of childhood B-ALL.

conclusionARID5B rs7089424 and rs10994982 might serve as genetic susceptibility markers for B-ALL in Chinese pediatric population. Moreover, the two ARID5B SNPs are associated with the risk of B-hyperdiploid ALL, which had a better therapeutic response than other ALL subtypes.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentChildChild, PreschoolDNA-Binding ProteinsFemaleGene FrequencyGenotypeHumansInfantMalePrecursor B-Cell Lymphoblastic Leukemia-LymphomaTranscription FactorsARID5B protein, humanDNA-Binding ProteinsTranscription Factors

Identifiers

PMID31274788
PMCPMC13048129
OpenAlexW2962033274

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.