SynthesisAsian journal of andrology
FSH dosage effect on conventional sperm parameters: a meta-analysis of randomized controlled studies.
Synthesis in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- The effectiveness of hormonal treatment to improve reproductive outcomes in normogonadotropic men with abnormal semen parameters: results of 2 linked systematic reviews.The Journal of clinical endocrinology and metabolism · 2026Pooled it
- The first Australian evidence-based guidelines on male infertility.The Medical journal of Australia · 2025Guideline
- Current treatment for male infertility: an umbrella review of systematic reviews and meta-analyses.Asian journal of andrology · 2024Pooled it
- Review
- Research progress on the multidimensional mechanisms underlying impaired spermatogenesis induced by pathological microenvironment remodeling in chronic prostatitis.Frontiers in immunology · 2026Review
- Recent advances in the management of male infertility.Asian journal of andrology · 2025Review
- The effect of in vitro use of FSH on sperm parameters, DNA integrity, and mitochondrial membrane potential in asthenozoospermic men.International urology and nephrology · 2025Article
- Testosterone replacement therapy and spermatogenesis in reproductive age men.Nature reviews. Urology · 2025Review
- Testicular index: clinical, applicable tool to predict pregnancy in men with idiopathic infertility under FSH treatment.Journal of endocrinological investigation · 2025Observational
- Yamabushitake Mushroom (International journal of molecular sciences · 2025Article
- Prospective Assessment of Gonadotropin Therapy and Its Outcome in Nonobstructive Azoospermic Patients.Cureus · 2025Article
- Current drawbacks and future perspectives in the diagnosis and treatment of male factor infertility, with a focus on FSH treatment: an expert opinion.Journal of endocrinological investigation · 2025Review
- Is There a Role for Hormonal Therapy in Men with Oligoasthenoteratozoospermia (OAT)?Journal of clinical medicine · 2024Review
- From Bench to Babies - Drug Development for Male Subfertility.Reproduction & fertility · 2024Article
- Effects of Switching FSH Preparations on Sperm Parameters and Pregnancy: A Prospective Controlled Study.Journal of clinical medicine · 2024Article
- Empirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines.Diseases (Basel, Switzerland) · 2024Review
- FSH Therapy in Male Factor Infertility: Evidence and Factors Which Might Predict the Response.Life (Basel, Switzerland) · 2024Review
- Are they functional hypogonadal men? Testosterone serum levels unravel male idiopathic infertility subgroups.Endocrine · 2024Article
- Combined evaluation of prolactin-induced peptide (PIP) and extracellular signal-regulated kinase (ERK) as new sperm biomarkers of FSH treatment efficacy in normogonadotropic idiopathic infertile men.Journal of endocrinological investigation · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Follicle-stimulating hormone (FSH) represents a therapeutic option in normogonadotropic patients with idiopathic oligozoospermia. The aim of this review was to evaluate the possible dose- and drug-dependent efficacy of FSH treatment on conventional sperm parameters. We performed a comprehensive systematic review via a meta-analysis of all available randomized controlled trials, in which FSH administration was compared with placebo or no treatment when administered to normogonadotropic patients with idiopathic oligozoospermia. Of the 971 articles that were retrieved, 5 were finally included, including a total of 372 patients and 294 controls. Overall, FSH treatment was effective in ameliorating the sperm concentration, total count, progressive motility, but not normal forms. On the basis of the weekly dosage, the studies were classified into those using low (175-262.5 IU per week), intermediate (350-525 IU per week), and high (700-1050 IU per week) doses. At low doses, FSH improved only sperm motility. At intermediate doses, FSH ameliorated sperm concentration and morphology. Total sperm count and progressive motility showed a trend toward the increase. At high doses, FSH increased sperm concentration, total sperm count, and progressive motility. Sperm morphology showed a trend toward the increase. Finally, both highly purified FSH (hpFSH) and recombinant human FSH (rhFSH) improved sperm concentration, total sperm count, progressive motility, but not morphology. No different efficacy was observed between these two preparations. This meta-analysis provides evidence in favor of high FSH doses. The FSH efficacy was not related to the preparation type (recombinant vs highly purified). Further studies are needed to evaluate the effectiveness of long-standing treatment regimes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.