Evidence map›Paper›PMID 31274355›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2019

Evidence of functional ryanodine receptors in rat mesenteric collecting lymphatic vessels.

Michiko Jo, Andrea N Trujillo, Ying Yang, Jerome W Breslin

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  3. Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Lymphatic Clearance and Pump Function.Cold Spring Harbor perspectives in medicine · 2023
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Roles of sarcoplasmic reticulum CaScientific reports · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Michiko JoDepartment of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Andrea N TrujilloDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Ying YangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Jerome W BreslinDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0003-4867-3151
University of South Florida · US

Funding

Molecular mechanisms enhancing lymphatic valve formationR01HL145397 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YANG, YING · 2019 to 2023
$1.9M
NHLBI NIH HHS L40 HL097863NHLBI NIH HHS R01 HL145397
6 · The paper itself

Abstract

In the current study, the potential contributions of ryanodine receptors (RyRs) to intrinsic pumping and responsiveness to substance P (SP) were investigated in isolated rat mesenteric collecting lymphatic vessels. Responses to SP were characterized in lymphatic vessels in the absence or presence of pretreatment with nifedipine to block L-type Ca

Indexed as

Calcium SignalingMuscle ContractionAnimalsCaffeineLymphatic VesselsMaleMesenteryMuscle, SmoothRats, Sprague-DawleyRyanodineRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSubstance PCaffeineRyanodineRyanodine Receptor Calcium Release ChannelRyr1 protein, ratRyR2 protein, ratSubstance Pcaffeinedantrolenelymphaticryanodine receptorsmooth muscle

Identifiers

PMID31274355
PMCPMC6766729
OpenAlexW2955855102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.