ArticleJournal of clinical hypertension (Greenwich, Conn.)2019
Association between cerebral microbleeds and hypertension in the Swedish general population "Good Aging in Skåne" study.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Imaging-validated correlates and implications of the pathophysiologic mechanisms of ageing-related cerebral large artery and small vessel diseases: a systematic review and meta-analysis.Behavioral and brain functions : BBF · 2025Pooled it
- Cerebral small vessel disease pathology in COVID-19 patients: A systematic review.Ageing research reviews · 2023Pooled it
- A European Academy of Neurology guideline on medical management issues in dementia.European journal of neurology · 2020Guideline
- Prevalence of Cerebral Microbleeds and Association With Vascular Risk Factors in a Hispanic and Latino American Cohort.Journal of the American Heart Association · 2026Article
- Article
- Does Ideal Blood Pressure Vary by Cognitive Domain? A UK Biobank Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- The burden of intracranial atherosclerosis on cerebral small vessel disease: A community cohort study.Annals of clinical and translational neurology · 2025Article
- Article
- Associations between cerebral small vessel disease and reduced forced vital capacity and expiratory volume in a general healthy Swedish elder population study-Good Aging in Skåne.Journal of Alzheimer's disease : JAD · 2025Article
- Development of cerebral microhemorrhages in a mouse model of hypertension.Journal of neuroinflammation · 2025Article
- Deep medullary vein dysfunction is associated with cerebral microbleeds in cerebral small vessel disease.Frontiers in human neuroscience · 2025Article
- Risk of Traumatic Intracranial Hemorrhage After Stroke: A Nationwide Population-Based Cohort Study in Taiwan.Journal of the American Heart Association · 2024Article
- Review
- Intermittent Metabolic Switching and Vascular Cognitive Impairment.Journal of obesity & metabolic syndrome · 2024Review
- Chronic kidney disease and its association with cerebral small vessel disease in the general older hypertensive population.BMC nephrology · 2024Article
- White matter changes, duration of hypertension, and age are associated with cerebral microbleeds in patients with different stages of hypertension.Quantitative imaging in medicine and surgery · 2022Article
- Sex Differences in Cognitive Impairment Induced by Cerebral Microhemorrhage.Translational stroke research · 2021Article
- Incident cerebral microbleeds and hypertension defined by the 2017 ACC/AHA Guidelines.Annals of translational medicine · 2021Article
- Association between cerebral microbleeds and hypertension in the Swedish general population "Good Aging in Skåne" study.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Risk Factor Analysis in Patients Exhibiting Cerebral Microbleeds and the Correlation with Cognitive Impairment.Gerontology & geriatric medicineArticle
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral microbleeds (CMB) on MRI are frequent in healthy aging individuals but precede ischemic and hemorrhagic stroke and dementia. Different etiologies have been suggested for nonlobar CMB, which have a stronger connection to hypertension (HT) than do lobar CMB. This study aimed to investigate the prevalence of CMB and the association between nonlobar/lobar CMB and different blood pressure (BP) and HT treatment conditions in a longitudinal, population-based cohort of the Good Aging in Skåne (GÅS) study. White matter hyperintensities (WMH), CMB, atrophies, and infarctions were identified with brain 3T MRI, and BP parameters were examined in 344 randomly selected subjects between 70 and 87 years old. CMB were observed in 26% of the whole cohort, increasing from 19% of subjects in their 70s to 30% of those over 80 years of age. Of these subjects, 38% had multiple CMB, and 59% had a lobar localization. CMB were associated with severe confluent WMH (odds ratio = 7.02; 2.16-18.84). Increasing age, being male, and having HT, impaired cognition, or a history of angina pectoris were associated with CMB. Both lobar and nonlobar CMB were associated with HT. Nonlobar CMB were particularly associated with increased BP, pulse pressure, controlled HT, and uncontrolled HT. After controlling for sex and HT, age was no longer a risk factor for CMB In conclusion, sex and HT are the major risk factors for CMB, especially nonlobar CMB, which suggests stricter implementation of recommended guidelines for HT treatment in the elderly.
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