ArticleMolecular plant pathology2019
Crosstalk between epigenetic silencing and infection by tobacco rattle virus in Arabidopsis.
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Positive-Strand RNA Viruses Induce LTR Retrotransposon Transcription and Extrachromosomal Circular DNA Generation in Plants.International journal of molecular sciences · 2025Article
- Tobacco rattle virus infection alters Arabidopsis gene expression via virus-derived SiRNAs and host MiRNA network disruption.BMC genomics · 2025Article
- Almond Grafting for Plum Pox Virus Resistance Triggers Significant Transcriptomic and Epigenetic Shifts in Peaches.International journal of molecular sciences · 2024Article
- Transcriptomic insights into the epigenetic modulation of turnip mosaic virus evolution in Arabidopsis thaliana.BMC genomics · 2024Article
- Identification of epigenetically regulated genes involved in plant-virus interaction and their role in virus-triggered induced resistance.BMC plant biology · 2024Article
- Adaptation of turnip mosaic virus toVirus evolution · 2024Article
- PSTVd infection inFrontiers in plant science · 2023Article
- Transgenerational Tolerance to Salt and Osmotic Stresses Induced by Plant Virus Infection.International journal of molecular sciences · 2022Article
- Turnip mosaic virus manipulates DRM2 expression to regulate host CHH and CHG methylation for robust infection.Stress biology · 2022Article
- Article
- The role of miRNA in plant-virus interaction: a review.Molecular biology reports · 2021Review
- Exploiting Epigenetic Variations for Crop Disease Resistance Improvement.Frontiers in plant science · 2021Review
- RdDM pathway components differentially modulate Tobamovirus symptom development.Plant molecular biology · 2020Article
- RNA-directed DNA Methylation.PLoS genetics · 2020Article
- Alterations of Rice (International journal of molecular sciences · 2020Article
- Epigenetic Changes in Host Ribosomal DNA Promoter Induced by an Asymptomatic Plant Virus Infection.Biology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is an important epigenetic mechanism for controlling innate immunity against microbial pathogens in plants. Little is known, however, about the manner in which viral infections interact with DNA methylation pathways. Here we investigate the crosstalk between epigenetic silencing and viral infections in Arabidopsis inflorescences. We found that tobacco rattle virus (TRV) causes changes in the expression of key transcriptional gene silencing factors with RNA-directed DNA methylation activities that coincide with changes in methylation at the whole genome level. Viral susceptibility/resistance was altered in DNA (de)methylation-deficient mutants, suggesting that DNA methylation is an important regulatory system controlling TRV proliferation. We further show that several transposable elements (TEs) underwent transcriptional activation during TRV infection, and that TE regulation likely involved both DNA methylation-dependent and -independent mechanisms. We identified a cluster of disease resistance genes regulated by DNA methylation in infected plants that were enriched for TEs in their promoters. Interestingly, TEs and nearby resistance genes were co-regulated in TRV-infected DNA (de)methylation mutants. Our study shows that DNA methylation contributes to modulate the outcome of viral infections in Arabidopsis, and opens up new possibilities for exploring the role of TE regulation in antiviral defence.
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