ArticleeLife2019
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Absence of TAAR1 function increases methamphetamine-induced excitability of dorsal raphe serotonin neurons and drives binge-level methamphetamine intake.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice.eLife · 2024Article
- Discovery and validation of genes driving drug-intake and related behavioral traits in mice.Genes, brain, and behavior · 2024Article
- Epistasis between mutator alleles contributes to germline mutation spectra variability in laboratory mice.bioRxiv : the preprint server for biology · 2023Article
- Rats have low motivation to self-administer oral methamphetamine across increasing response requirements.Behavioural brain research · 2023Article
- Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice.Communications biology · 2023Article
- Robust aversive effects of trace amine-associated receptor 1 activation in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- DISCOVERY AND VALIDATION OF GENES DRIVING DRUG-INTAKE AND RELATED BEHAVIORAL TRAITS IN MICE.bioRxiv : the preprint server for biology · 2023Article
- Trace amine-associated receptor 1 and drug abuse.Advances in pharmacology (San Diego, Calif.) · 2022Article
- Combined and sequential effects of alcohol and methamphetamine in animal models.Neuroscience and biobehavioral reviews · 2021Review
- Integration of evidence across human and model organism studies: A meeting report.Genes, brain, and behavior · 2021Review
- Article
- A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.Genes, brain, and behavior · 2021Article
- Confirmation of a CausalFrontiers in psychiatry · 2021Article
- Non-genetic factors that influence methamphetamine intake in a genetic model of differential methamphetamine consumption.Psychopharmacology · 2020Article
- Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder.Pharmacology & therapeutics · 2020Review
- Facilitating Complex Trait Analysis via Reduced Complexity Crosses.Trends in genetics : TIG · 2020Review
- 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs.Genes, brain, and behavior · 2020Article
- Methamphetamine Activates Trace Amine Associated Receptor 1 to Regulate Astrocyte Excitatory Amino Acid Transporter-2 via Differential CREB Phosphorylation During HIV-Associated Neurocognitive Disorders.Frontiers in neurology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Alexandra M Stafford *Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, United States.ORCID 0000-0003-4045-1888
Cheryl Reed *Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, United States.ORCID 0000-0002-8798-2347
Harue BabaDepartment of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, United States.
Nicole Ar WalterDivision of Neuroscience, Oregon National Primate Research Center, Portland, United States.
John Rk MootzDepartment of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, United States.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Sciences Center, Memphis, United States.
Kim A NeveDepartment of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, United States.ORCID 0000-0003-0109-7345
Lev M FedorovTransgenic Mouse Models Shared Resource, Knight Cancer Institute, Oregon Health & Science University, Portland, United States.
Aaron J JanowskyDepartment of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, United States.
Tamara J PhillipsDepartment of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, United States.ORCID 0000-0002-7350-6323
Oregon Health & Science University · USOregon National Primate Research Center · USUniversity of Tennessee Health Science Center · US
Funding
TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI William L. Dewey · 1985 to 2026
$14.7MTraditional Service Core [Translational Service Core (TSC)]P50DA018165 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BELKNAP, JOHN K · 2006 to 2016
$13.0MBIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4MTIM Project NIDA P30 CenterP30DA044223 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2017 to 2021
$3.9MGenetic Risk for Methamphetamine AbuseU01DA041579 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2016 to 2020
$2.1MGenetic Factors Underlying Risk for Methamphetamine Intake and Associated TraitsR01DA046081 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2018 to 2022
$1.7MOpioid Sensitive GABA inputs to the Ventral MidbrainR01DA034388 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 2012 to 2016
$967kGenetic basis of methamphetamine intakeI01BX002106 · VA · PORTLAND VA MEDICAL CENTER · PI PHILLIPS, TAMARA J. · 2014 to 2022
–Dopamine D2 Receptor Splice Variants and Autoreceptor FunctionI01BX003279 · VA · PORTLAND VA MEDICAL CENTER · PI NEVE, KIM ARTHUR · 2017 to 2020
–BLRD VA I01 BX002106BLRD VA I01 BX002758BLRD VA I01 BX003279BLRD VA IK6 BX006342NIDA NIH HHS P30 DA044223NIDA NIH HHS P50 DA018165NIDA NIH HHS R01 DA034388NIDA NIH HHS R01 DA046081NIDA NIH HHS T32 DA007027NIDA NIH HHS T32 DA007262NIDA NIH HHS U01 DA041579VA I01BX002106VA I01BX002758VA I01BX003279
Abstract
We identified a locus on mouse chromosome 10 that accounts for 60% of the genetic variance in methamphetamine intake in mice selectively bred for high versus low methamphetamine consumption. We nominated the trace amine-associated receptor 1 gene,
Indexed as
Genetic VariationAnimalsBase SequenceBody TemperatureChromosomes, MammalianFemaleGenotypeHypothermiaMaleMethamphetamineMiceQuantitative Trait LociReceptors, G-Protein-CoupledReceptors, Opioid, muTrace Amine-Associated ReceptorsMethamphetamineOprm protein, mouseReceptors, G-Protein-CoupledReceptors, Opioid, muTrace Amine-Associated ReceptorsaddictionCRISPR-Cas9geneticsgenomicshypothermiamousemu-opioid receptorneuroscienceself administrationtrace amine-associated receptor 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.