ArticleThe journal of physiological sciences : JPS2019
Effects of astaxanthin supplementation and electrical stimulation on muscle atrophy and decreased oxidative capacity in soleus muscle during hindlimb unloading in rats.
Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Whey Protein Isolate-Encapsulated Astaxanthin Nanoemulsion More Effectively Mitigates Skeletal Muscle Atrophy in Dexamethasone-Induced Mice.Nutrients · 2025Article
- Methylglyoxal reduces resistance exercise-induced protein synthesis and anabolic signaling in rat tibialis anterior muscle.Journal of muscle research and cell motility · 2024Article
- Niacin supplementation attenuates the regression of three-dimensional capillary architecture in unloaded female rat skeletal muscle.Physiological reports · 2024Article
- High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats.Acta histochemica et cytochemica · 2023Article
- Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.European journal of nutrition · 2023Article
- Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins.Neural regeneration research · 2021Article
- Article
- Altering aspects of mitochondrial quality to improve musculoskeletal outcomes in disuse atrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Effects of astaxanthin on the protection of muscle health (Review).Experimental and therapeutic medicine · 2020Review
- Improved Tetanic Force and Mitochondrial Calcium Homeostasis by Astaxanthin Treatment in Mouse Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2020Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The effects of a combination of the antioxidant astaxanthin (AX) and electrical stimulation (ES) on muscle mass and mitochondrial oxidative capacity were investigated in the soleus muscle of hindlimb unloaded rats. Five groups of male Sprague-Dawley rats were used; control, 1-week hindlimb unloading (HU), HU + AX, HU + ES, and HU + AX + ES. Respective rats in the AX groups received 50-mg/kg AX twice daily during HU. Calf muscles of rats in the ES groups were electrically stimulated for 240 s/day during HU. One-week HU decreased muscle mass along with decreased FoxO3a phosphorylation and increased ubiquitinated proteins expressions, decreased oxidative enzymatic activity accompanied with decline in PGC-1α protein expression, and increased reactive oxygen species production. However, the combination treatment could synergistically attenuate/suppress all HU-related changes, suggesting protective effects on muscle atrophy and decreased muscle oxidative capacity due to chronic neuromuscular inactivity.
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