ArticleBrain imaging and behavior2020
Neuroanatomical correlates of apathy and disinhibition in behavioural variant frontotemporal dementia.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The relationship between apathy and impulsivity in large population samples.Scientific reports · 2021Trial
- Elucidating the Neurobiological Underpinnings of Mild Behavioral Impairment in Tauopathies: Clinical and Molecular Insights.International journal of molecular sciences · 2026Review
- The Cortico-Cortical and Subcortical Circuits of the Human Brain Language Centers Including the Dual Limbic and Language Functioning Fiber Tracts.Brain sciences · 2026Review
- Article
- Criminal Behavior in Frontotemporal Dementia: A Multimodal MRI Study.Human brain mapping · 2025Article
- Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia.Brain imaging and behavior · 2024Article
- Atrophy network mapping of clinical subtypes and main symptoms in frontotemporal dementia.Brain : a journal of neurology · 2024Article
- Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia.Brain imaging and behavior · 2024Article
- Behavioral disinhibition in stroke.Frontiers in neurology · 2024Article
- An attentional and working memory theory of hallucination vulnerability in frontotemporal dementia.Brain communications · 2024Article
- Neuropsychiatric symptoms and imbalance of atrophy in behavioral variant frontotemporal dementia.Human brain mapping · 2023Article
- Changes in motor activity level in individuals with frontotemporal dementia.Journal of neurology · 2023Article
- Frontotemporal Dementia, Where Do We Stand? A Narrative Review.International journal of molecular sciences · 2023Review
- Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales.Scientific reports · 2023Article
- Apathy in Patients With Cerebral Amyloid Angiopathy: A Multimodal Neuroimaging Study.Neurology · 2023Article
- Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia.Neurobiology of aging · 2023Article
- The Differential Role of Executive Apathy in Alzheimer's Disease Dementia, Mild Cognitive Impairment and Healthy Cognitive Ageing.Geriatrics (Basel, Switzerland) · 2023Article
- Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights.Brain : a journal of neurology · 2023Article
- Temporopolar regions of the human brain.Brain : a journal of neurology · 2023Article
- Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference.Network neuroscience (Cambridge, Mass.) · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
Neuroanatomical correlates of apathy and disinhibition, behavioral abnormalities in behavioral variant Frontotemporal dementia (bvFTD) remain unclear. In this study 45 participants (25 bvFTD patients and 20 controls) provided data on clinical, neuropsychological, behavioral (on Frontal Systems Behavior (FrSBe) Scale), cortical volume (on voxel-based morphometry (VBM)) and tract based spatial fractional anisotropy ((FA) on magnetic resonance imaging (MRI), allowing examination of the neural correlates of apathy and disinhibition. The patients with bvFTD had predominant grey matter loss and corresponding white matter fractional anisotropy reduction in the frontal and temporal lobe compared to the controls. Grey matter loss in frontal, temporal and limbic structures correlated with apathy and degeneration in temporal limbic brain areas correlated with disinhibition. FA changes in inferior fronto-occipital fasciculus and forceps minor correlated with apathy and fibre integrity changes in the superior longitudinal fasciculus correlated with disinhibition. The current study suggests that apathy and disinhibition arises due to changes in the frontal, temporal and limbic brain areas in bvFTD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.