ArticleClinical rheumatology2019
Clinicopathologic features of rheumatoid nodules: a retrospective analysis.
Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Risk factors for incidence of interstitial lung disease in patients with rheumatoid arthritis: a systematic review and meta-analysis.BMJ open respiratory research · 2024Pooled it
- Article
- Rheumatoid vasculitis presenting in the absence of rheumatoid arthritis: a case-based review.Rheumatology international · 2025Review
- Recurrently Infected Rheumatoid Nodule Causing Posterior Interosseous Nerve Palsy: A Report of a Rare Case.Cureus · 2025Article
- Noninfectious Granulomatous Lung Disease: Radiological Findings and Differential Diagnosis.Journal of personalized medicine · 2024Review
- Rheumatoid nodules: a narrative review of histopathological progression and diagnostic consideration.Clinical rheumatology · 2023Review
- An Unusual and Rare Location of Intra-articular Rheumatoid Nodule in the Elbow Joint - A Case Report.Cureus · 2023Article
- Outcomes and Complications of Corticosteroid Injection of Rheumatoid Nodules.The Journal of clinical and aesthetic dermatology · 2022Article
- Non-Infectious Granulomatous Lung Disease: Imaging Findings with Pathologic Correlation.Korean journal of radiology · 2021Review
- [Rheumatoid arthritis of the hand : Part 2: Imaging].Der Radiologe · 2021Review
- Endothelial Dysfunction and Extra-Articular Neurological Manifestations in Rheumatoid Arthritis.Biomolecules · 2021Review
- A giant rheumatoid nodule of the cubital fossa: A mimicker of malignancy.Journal of family medicine and primary care · 2020Article
- Facial Subcutaneous Nodule as the First Presentation Finding in a Patient with Rheumatoid Arthritis.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe clinical and histopathologic features of patients that have been diagnosed with rheumatoid nodules were investigated.
methodsThis study included patients with rheumatoid nodules, confirmed by histologic assessment, between 2005 and 2018 at the Hanyang University Hospital. Each patient had a total score of 6 or more according to the American College of Rheumatology criteria.
resultsA total of 57 cases were included in this study. The median age of the patients at the time of diagnosis was 57 years (range, 39-70 years). The average duration between the onset of treatment and occurrence of rheumatoid nodule was 11.6 years. Bone erosion was observed in 44 patients (77.2%). Among 57 patients, 56 (98.2%) were treated with disease-modifying anti-rheumatic drugs; most of the patients (87.7%) showed high-positive rheumatoid factor or high-positive anti-citrullinated protein antibodies. The foot, hand, and wrist, in order of decreasing frequencies, were the anatomical sites with the highest occurrence of rheumatoid nodules, whereas, the soft tissue adjacent to the joint, subcutis, dermis, lung parenchyma, and submucosal layer of the supraglottic area, also in an order of highest frequency, were the histological sites with the highest occurrence. Microscopically, central necrobiosis was present in all cases. Stromal fibrosis (96.5%), palisading of histiocytes (82.5%), perivascular lymphocytic infiltration (68.4%), and cleft or cystic degeneration (63.2%) were also observed.
conclusionsA clinicopathological review of cases diagnosed with rheumatoid nodules histologically was performed to confirm characteristics that can help clinicians understand the pathophysiology of the condition and make accurate diagnoses of rheumatoid nodules. Key Points • We reviewed the clinical, imaging, and histologic features of rheumatoid nodule. • The average duration between the onset of treatment and occurrence of rheumatoid nodule was 11.6 years. • Among 57 rheumatoid nodule patients, 98.2% were treated with disease-modifying anti-rheumatic drugs.
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