ArticleThe international journal of cardiovascular imaging2019
Coronary artery disease risk reclassification by a new acoustic-based score.
Article in The international journal of cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Diagnostic performance of coronary artery disease prediction model (CAD-score system) based on phonocardiogram: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Acoustic-based rule-out of stable coronary artery disease: the FILTER-SCAD trial.European heart journal · 2025Trial
- Diagnostic performance of a device for acoustic heart sound analysis in patients with suspected myocardial infarction.Open heart · 2023Trial
- Coronary artery disease diagnosis with signal processing and machine learning of heart sound signals: a systematic review.NPJ digital medicine · 2026Article
- Optimizing diagnostic resource use in suspected chronic coronary syndrome: pre-test probability and acoustic CAD rule-out in the FILTER-SCAD trial.European heart journal. Digital health · 2026Article
- Diagnostic performance of combined biomarkers and phonocardiography vs. the 2024 ESC risk factor-weighted clinical likelihood model for detecting coronary artery disease.European heart journal. Imaging methods and practice · 2026Article
- Cost-Effectiveness of the CADScor System in Low-Risk Patients Presenting to the Emergency Department with Chest Pain.PharmacoEconomics - open · 2025Article
- Pre-test probability estimation of coronary artery disease can be improved by adding an acoustic-based risk score.International journal of cardiology. Heart & vasculature · 2025Article
- Accurate Localization of First and Second Heart Sounds via Template Matching in Forcecardiography Signals.Sensors (Basel, Switzerland) · 2024Article
- Improved pre-test likelihood estimation of coronary artery disease using phonocardiography.European heart journal. Digital health · 2022Article
- The Feasibility of Ultra-Sensitive Phonocardiography in Acute Chest Pain Patients of a Tertiary Care Emergency Department (ScorED Feasibility Study).Journal of personalized medicine · 2022Article
- Economic Analysis of the CADScor System for Ruling Out Coronary Artery Disease in England.PharmacoEconomics - open · 2022Article
- Article
- Prospective validation of an acoustic-based system for the detection of obstructive coronary artery disease in a high-prevalence population.Heart and vessels · 2021Article
- Advanced heart sound analysis as a new prognostic marker in stable coronary artery disease.European heart journal. Digital health · 2021Article
- Sortilin as a Biomarker for Cardiovascular Disease Revisited.Frontiers in cardiovascular medicine · 2021Article
- Letter by Garcia A, et al. regarding article: Coronary artery disease risk reclassification by a new acoustic-based score.The international journal of cardiovascular imaging · 2020Article
- Coronary artery disease risk reclassification using an acoustic-based score in view of the new European Society of Cardiology 2019 guidelines on Chronic Coronary Syndromes.The international journal of cardiovascular imaging · 2020Article
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the potential of a non-invasive acoustic device (CADScor®System) to reclassify patients with intermediate pre-test probability (PTP) and clinically suspected stable coronary artery disease (CAD) into a low probability group thereby ruling out significant CAD. Audio recordings and clinical data from three studies were collected in a single database. In all studies, patients with a coronary CT angiography indicating CAD were referred to coronary angiography. Audio recordings of heart sounds were processed to construct a CAD-score. PTP was calculated using the updated Diamond-Forrester score and patients were classified according to the current ESC guidelines for stable CAD: low < 15%, intermediate 15-85% and high > 85% PTP. Intermediate PTP patients were re-classified to low probability if the CAD-score was ≤ 20. Of 2245 patients, 212 (9.4%) had significant CAD confirmed by coronary angiography ( ≥ 50% diameter stenosis). The average CAD-score was higher in patients with significant CAD (38.4 ± 13.9) compared to the remaining patients (25.1 ± 13.8; p < 0.001). The reclassification increased the proportion of low PTP patients from 13.6% to 41.8%, reducing the proportion of intermediate PTP patients from 83.4% to 55.2%. Before reclassification 7 (3.1%) low PTP patients had CAD, whereas post-reclassification this number increased to 28 (4.0%) (p = 0.52). The net reclassification index was 0.209. Utilization of a low-cost acoustic device in patients with intermediate PTP could potentially reduce the number of patients referred for further testing, without a significant increase in the false negative rate, and thus improve the cost-effectiveness for patients with suspected stable CAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.