Evidence map›Paper›PMID 31273568›Full record

ArticleJournal of abnormal child psychology2019

Depression and ADHD-Related Risk for Substance Use in Adolescence and Early Adulthood: Concurrent and Prospective Associations in the MTA.

Andrea L Howard, Traci M Kennedy, Erin P Macdonald, John T Mitchell, Margaret H Sibley, Arunima Roy, L Eugene Arnold, Jeffery N Epstein, Stephen P Hinshaw, Betsy Hoza and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of abnormal child psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 2 countries.

Andrea L HowardDepartment of Psychology, Carleton University, Ottawa, ON, K1S 5B6, Canada. andrea.howard@carleton.ca.ORCID 0000-0002-9843-9577
Traci M KennedyDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Erin P MacdonaldDepartment of Psychology, Carleton University, Ottawa, ON, K1S 5B6, Canada.
John T MitchellDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Margaret H SibleyDepartment of Psychiatry, Florida International University, Miami, FL, USA.
Arunima RoyDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
L Eugene ArnoldDepartment of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA.
Jeffery N EpsteinDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Stephen P HinshawDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA.
Betsy HozaDepartment of Psychological Science, University of Vermont, Burlington, VT, USA.
Annamarie StehliDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
James M SwansonDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
Brooke S G MolinaDepartments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Carleton University · CAUniversity of California, Irvine · USUniversity of Pittsburgh · USDuke Medical Center · USFlorida International University · USThe Ohio State University · USUniversity of California, Berkeley · USUniversity of Cincinnati Medical Center · USUniversity of Ottawa · CAUniversity of Vermont · US

Funding

Pathways to adult substance use and abuse from childhood ADHD in the MTAR01DA039881 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2015 to 2018
$1.1M
MULTISITE MULTIMODALITY TREATMENT STUDY OF ADHD/ADDU01MH050440 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI SWANSON, JAMES M · 1992 to 2000
$17k
MULTISITE MULTIMODAL TREATMENT STUDY OF ADHD/ADDU01MH050453 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABIKOFF, HOWARD B · 1992 to 2000
$17k
PHARMACOLOGIC AND PSYCHOSOCIAL INTERVENTIONS FOR ADHDU01MH050461 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HINSHAW, STEPHEN P · 1992 to 2000
$17k
PHARMACOLOGICAL AND PSYCHOSOCIAL TREATMENT FOR ADHDU01MH050467 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PELHAM, WILLIAM E · 1992 to 2000
$17k
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012011N01MH012011 · NIMH · UNIVERSITY OF CALIFORNIA, IRVI · PI SWANSON, JAMES · 2002 to 2006
–
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012004N01MH012004 · NIMH · NEW YORK UNIVERSITY SCHOOL OF · PI ABIKOFF, HOWARD BARRY · 2002 to 2006
–
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012012N01MH012012 · NIMH · DUKE UNIVERSITY MEDICAL CENTER · 2002 to 2004
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FOLLOW UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012007N01MH012007 · NIMH · RES. FOUND. FOR MENTAL HEALTH, · PI GREENHILL, LARRY LEE · 2002 to 2006
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012008N01MH012008 · NIMH · MCGILL UNIVERSITY · PI HECHTMAN, LILY T. · 2002 to 2006
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012009N01MH012009 · NIMH · UNIVERSITY OF CALIFORNIA, BERK · PI HINSHAW, STEPHEN · 2002 to 2006
–
FOLLOW UP OF THE MULTIMODAL TREATMETN STUDY OF CHILDREN WITH ATTENTION-278012010N01MH012010 · NIMH · UNIVERSITY OF PITTSBURGH · PI SG MOLINA, BROOKE · 2002 to 2006
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NIDA NIH HHS N01 DA085548NIDA NIH HHS N01 DA085549NIDA NIH HHS N01 DA085550NIDA NIH HHS N01 DA085551NIDA NIH HHS N01 DA085552NIDA NIH HHS N01 DA085553NIDA NIH HHS N01 DA085554NIDA NIH HHS R01 DA039881NIMH NIH HHS N01 MH012004NIMH NIH HHS N01 MH012007NIMH NIH HHS N01 MH012008NIMH NIH HHS N01 MH012009NIMH NIH HHS N01 MH012010NIMH NIH HHS N01 MH012011NIMH NIH HHS N01 MH012012NIMH NIH HHS U01 MH050440NIMH NIH HHS U01 MH050453NIMH NIH HHS U01 MH050461NIMH NIH HHS U01 MH050467NIMH NIH HHS U01MH50477
6 · The paper itself

Abstract

Childhood attention-deficit/hyperactivity disorder (ADHD) is prospectively linked to substance use and disorder. Depression emerging in adolescence is an understudied risk factor that may explain some of this risk. In the present study, we considered mediating and moderating roles of adolescent depression in explaining this association by using longitudinal data from the prospective 16-year follow-up of the Multimodal Treatment Study of ADHD (MTA). Participants were 547 children diagnosed with DSM-IV ADHD Combined Type, and 258 age- and sex-matched comparison children. In adolescence, depressive symptoms did not exacerbate effects of childhood ADHD on any substance use. For both groups, time-varying and average depressive symptoms were associated with more frequent use of all substances. Prospectively, we found no evidence of depression mediation to adult substance use. However, adolescent depression moderated the association between childhood ADHD and adult marijuana use. Although adults without ADHD histories used marijuana more frequently if they had elevated depressive symptoms in adolescence, marijuana use by adults with ADHD histories was independent of their adolescent depression. In adulthood, depression diagnoses and ADHD persistence continued to operate as independent, additive correlates of substance use risk. Our findings suggest a circumscribed role for depression in substance use risk that adds to, but does not alter or explain, ADHD-related risk.

Indexed as

AdolescentAdultAttention Deficit Disorder with HyperactivityChildDepressionFemaleHumansLongitudinal StudiesMaleRiskSubstance-Related DisordersYoung AdultADHDAdolescenceDepressionEarly adulthoodLongitudinalSubstance use

Identifiers

PMID31273568
PMCPMC6842691
OpenAlexW2955823828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.