ArticleJournal of materials science. Materials in medicine2019
Human hair keratins promote the regeneration of peripheral nerves in a rat sciatic nerve crush model.
Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Neurotrophic factors combined with stem cells in the treatment of sciatic nerve injury in rats: a meta-analysis.Bioscience reports · 2022Pooled it
- Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators.Molecular medicine reports · 2025Article
- Small fiber neuropathy in epidermolysis bullosa simplex.JAAD case reports · 2024Article
- Multiprotein collagen/keratin hydrogel promoted myogenesis and angiogenesis of injured skeletal muscles in a mouse model.BMC biotechnology · 2024Article
- Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends.International journal of molecular sciences · 2022Review
- Electrospun non-wovens potential wound dressing material based on polyacrylonitrile/chicken feathers keratin nanofiber.Scientific reports · 2022Article
- Sustainable Applications of Animal Waste Proteins.Polymers · 2022Review
- Bioactive Low Molecular Weight Keratin Hydrolysates for Improving Skin Wound Healing.Polymers · 2022Article
- Biomaterial and Therapeutic Approaches for the Manipulation of Macrophage Phenotype in Peripheral and Central Nerve Repair.Pharmaceutics · 2021Review
- Bio-Scaffolds as Cell or Exosome Carriers for Nerve Injury Repair.International journal of molecular sciences · 2021Review
- Keratin Biomaterials in Skin Wound Healing, an Old Player in Modern Medicine: A Mini Review.Pharmaceutics · 2021Review
- Polymer Scaffolds for Biomedical Applications in Peripheral Nerve Reconstruction.Molecules (Basel, Switzerland) · 2021Review
- Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury.Biomaterials · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axon regeneration and functional recovery after peripheral nerve injury remains a clinical challenge. Injury leads to axonal disintegration after which Schwann cells (SCs) and macrophages re-engage in the process of regeneration. At present, biomaterials are regarded as the most promising way to repair peripheral nerve damage. As a natural material, keratin has a wide range of sources and has good biocompatibility and biodegradability. Here, a keratin was extracted from human hair by reducing method and a keratin sponge with porous structure was obtained by further processing. The results suggested that keratin can promote cell adhesion, proliferation, migration as well as the secretion of neurotrophic factors by SCs and the regulation of the expression of macrophage inflammatory cytokines in vitro. We report for the first time that human hair keratin can promote the extension of axon in DRG neurons. The motor deficits caused by a sciatic nerve crush injury were alleviated by keratin sponge dressing in vivo. Thus, keratin has been identified as a valuable biomaterial that can enhance peripheral nerve regeneration.
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Registered trials
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