ReviewSkeletal radiology2020
Whole-body MRI in assessing malignant transformation in multiple hereditary exostoses and enchondromatosis: audit results and literature review.
Review in Skeletal radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Whole-body MRI for staging and follow-up of primary musculoskeletal tumours: a systematic review.The British journal of radiology · 2026Pooled it
- Whole-body imaging for distant staging of bone chondrosarcoma: a systematic review.La Radiologia medica · 2025Pooled it
- Nationwide epidemiologic study of osteochondroma in Japan: Analysis of 4843 cases from the bone and soft tissue tumor registry.Journal of bone oncology · 2026Article
- Article
- Hereditary multiple exostoses: an educational review.Insights into imaging · 2025Article
- Update on Cancer Screening in Children with Syndromes of Bone Lesions, Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome, and Other Rare Syndromes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Review
- Paediatric Calcaneal Osteochondroma: A Case Report and a Literature Review.Diseases (Basel, Switzerland) · 2024Article
- Unusual soft tissue metastases in a patient with chondrosarcoma: a case report.International cancer conference journal · 2024Article
- Hand Radiographs in Skeletal Dysplasia: A Pictorial Review.The Indian journal of radiology & imaging · 2024Review
- Is total-body MRI useful as a screening tool to rule out malignant progression in patients with multiple osteochondromas? Results in a single-center cohort of 319 adult patients.Skeletal radiology · 2024Article
- Article
- Concurrent intraosseous cartilaginous lesions in patients with multiple osteochondromas identified on total-body MR imaging.Skeletal radiology · 2023Article
- Premalignant Conditions of Bone.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Update on the imaging features of the enchondromatosis syndromes.Skeletal radiology · 2022Review
- An update on the imaging of diaphyseal aclasis.Skeletal radiology · 2021Review
- Endoscopic endonasal extreme far-medial approach for a lower clivus osteochondroma in a patient with hereditary multiple exostoses: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Diagnostic Value of CT- and MRI-Based Texture Analysis and Imaging Findings for Grading Cartilaginous Tumors in Long Bones.Frontiers in oncology · 2021Article
- Hereditary Multiple Exostoses-A Review of the Molecular Background, Diagnostics, and Potential Therapeutic Strategies.Frontiers in genetics · 2021Review
- The value of chest and skeletal staging studies in conventional chondrosarcoma.Skeletal radiology · 2021Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the results of annual screening using whole-body magnetic resonance imaging (WBMRI) in patients with multiple hereditary exostoses (MHE) and enchondromatosis (EC), and estimate the risk for transformation to chondrosarcoma (CS) in these disorders. MATERIALS AND
methodsA total of 62 patients (57 with MHE and five with EC) screened during a mean follow-up period of 4.6 years (range, 1-10 years) using 253 WBMRIs (median four WBMRIs per patient, range, 1-10) were analyzed retrospectively. The time of WBMRIs was compared with dates for diagnosed CSs. A supplementary literature review was performed focusing on the risk of malignant transformation.
resultsTen patients had CS before being enrolled in the screening program, nine with MHE and one with EC. Three asymptomatic CSs were detected by screening; one in a patient with EC and two in patients with MHE, one of whom had CS previously. During the screening period, there was no occurrence of CS not detected by WBMRI in the study group. Histopathologically, the CSs were predominantly grade 1 and were, except for in two patients, located at the truncus, proximal femur, and shoulder girdle. Based on the current material and literature review, the risk of CS seems to be in the range of 2-3.7% for MHE and up to 50% for EC patients.
conclusionsMRI may be used as a screening method detecting malignant transformation in MHE and EC patients, but the efficacy has to be confirmed in long-term follow-up studies including cost analysis.
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Registered trials
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