Evidence map›Paper›PMID 31273339›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2019

Prehypertension exercise training attenuates hypertension and cardiac hypertrophy accompanied by temporal changes in the levels of angiotensin II and angiotensin (1-7).

Wen-Wen Peng, Lin Hong, Guo-Ying Liu, Cheng Lin, Xiao-Lin Zhao, Shi-Zhong Wang, Li Lin, Yan-Xia Pan

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wen-Wen Peng *Department of Rehabilitation Therapy, College of Medical Technology and Engineering, Fujian Medical University, 350004, Fuzhou, China.
Lin Hong *Department of Rehabilitation Therapy, College of Medical Technology and Engineering, Fujian Medical University, 350004, Fuzhou, China.
Guo-Ying LiuDepartment of Rehabilitation Therapy, College of Medical Technology and Engineering, Fujian Medical University, 350004, Fuzhou, China.
Cheng LinDepartment of Rehabilitation Therapy, College of Medical Technology and Engineering, Fujian Medical University, 350004, Fuzhou, China.
Xiao-Lin ZhaoDepartment of Rehabilitation Therapy, College of Medical Technology and Engineering, Fujian Medical University, 350004, Fuzhou, China.
Shi-Zhong WangDepartment of Rehabilitation Therapy, College of Medical Technology and Engineering, Fujian Medical University, 350004, Fuzhou, China.
Li LinKey Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University, 200120, Shanghai, China.
Yan-Xia PanDepartment of Rehabilitation Therapy, College of Medical Technology and Engineering, Fujian Medical University, 350004, Fuzhou, China. ypan266@fjmu.edu.cn.
Fujian Medical University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Appropriate exercise training (ExT) has been shown to decrease high blood pressure. Accumulating data have indicated the beneficial effects of ExT on prehypertension. This study tested whether prehypertension ExT protects against hypertension and cardiac remodeling in spontaneously hypertensive rats (SHR) and explored the underlying mechanisms by examining the cardiac angiotensin-converting enzyme (ACE) and ACE2 signaling axes. Low-intensity ExT was started in male SHR and control Wistar-Kyoto rats prior to the onset of hypertension and maintained for 8 or 16 weeks. Blood pressure (BP) was measured biweekly by the tail-cuff method. Cardiac function and remodeling were assessed, and changes in the ACE and ACE2 axes were examined after the final ExT session. The results showed that prehypertension ExT slowed the onset and progression of hypertension in SHR. In parallel, hypertrophy in the hearts of hypertensive rats was attenuated, myocardial fibrosis was reduced, and impairment of left ventricular diastolic function was reduced. In the SHR myocardium, the levels of components involved in the ACE-Ang II-AT1 axis were homogeneously and progressively increased, whereas those involved in the ACE2-Ang(1-7)-MAS axis were heterogeneously decreased. Different temporal responses were observed for the key effectors Ang II and Ang(1-7). Myocardial Ang II levels were progressively increased in SHR and were consistently reduced by ExT. By contrast, Ang(1-7) decreased only after 16 weeks of sedentariness, and this decrease was abolished by ExT. In addition, 16 weeks of ExT increased the levels of Ang(1-7) in normotensive control rats. In summary, prehypertension ExT attenuates hypertension and cardiac remodeling. Downregulation of Ang II seems to serve as a protective mechanism during ExT, while upregulation of Ang(1-7) is induced after a relatively long period of ExT.

Indexed as

Angiotensin-Converting Enzyme 2Angiotensin IAngiotensin IIAnimalsBlood PressureCardiomegalyDiastoleMaleMyocardiumPeptide FragmentsPeptidyl-Dipeptidase APhysical Conditioning, AnimalPrehypertensionRats, Inbred SHRRats, Inbred WKYVentricular RemodelingAce2 protein, ratAngiotensin-Converting Enzyme 2Angiotensin Iangiotensin I (1-7)Angiotensin IIPeptide FragmentsPeptidyl-Dipeptidase ACardiac remodelingExercise trainingHypertensionPrehypertensionRenin–angiotensin system

Identifiers

PMID31273339
OpenAlexW2955815923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.