ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2020
Interobserver variation in the assessment of the sarcomatoid and transitional components in biphasic mesotheliomas.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 34 citations in OpenAlex.
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- Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Review
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- A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images.Nature communications · 2025Article
- Cytoplasmic HuR Expression Enhances Chemoresistance in Pleural Mesothelioma Through Increased Expression of CALB2, Promotion of the E2F Pathway, and Suppression of the p53 Pathway.Thoracic cancer · 2025Article
- MesoGraph: Automatic profiling of mesothelioma subtypes from histological images.Cell reports. Medicine · 2023Article
- Automated Nuclear Segmentation in Head and Neck Squamous Cell Carcinoma Pathology Reveals Relationships between Cytometric Features and ESTIMATE Stromal and Immune Scores.The American journal of pathology · 2022Article
- Review
- Pleural mesothelioma classification-update and challenges.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Review
- When the Diagnosis of Mesothelioma Challenges Textbooks and Guidelines.Journal of clinical medicine · 2021Review
- Pleural mesothelioma classification update.Virchows Archiv : an international journal of pathology · 2021Review
- Interobserver Agreement in Histopathological Subtyping of Malignant Pleural Mesotheliomas.Turk patoloji dergisi · 2021Article
- Update on the pathologic diagnosis of malignant mesothelioma.Translational lung cancer research · 2020Review
- Clinical significance of histologic subtyping of malignant pleural mesothelioma.Translational lung cancer research · 2020Review
- Review
- Sarcomatoid Mesothelioma with Bland Histologic Features: A Potential Pitfall in Diagnosis.AJSP: reviews & reportsArticle
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15 authors at 11 institutions in 5 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The percentage of sarcomatoid component has an impact on prognosis in patients with biphasic malignant pleural mesothelioma. Recent study showed that the transitional pattern similar to sarcomatoid component of malignant mesothelioma has negative prognostic significance. Practice guidelines recommend quantification of sarcomatoid component despite poor diagnostic reproducibility of biphasic mesothelioma among thoracic pathologists. The aim of this study was to determine the interobserver agreement in the quantification of sarcomatoid component, and in the diagnosis of a transitional component in the biphasic malignant mesothelioma. Thirteen experts in thoracic pathology reviewed the representative H&E and cytokeratin whole-slide images of the 54 biphasic mesotheliomas, without knowledge of BAP1 or p16 deletion status, and completed the survey of 25 questions. The overall interobserver agreement in the assessment of the percentage of the sarcomatoid component in 25% increments was good (wK = 0.62). Excellent agreement was present in 14 of 54 cases (26%), and 3 cases were unanimously scored. Excellent agreement was reached for the cases with 0-24% and > 75% of the sarcomatoid component.The most commonly used criteria for the diagnosis of sarcomatoid component were malignant spindle cells, frank sarcomatoid features and high N/C ratio. The overall interobserver agreement for transitional pattern was fair (wK = 0.40). Unanimous opinion about the absence of transitional pattern was observed in only one case. At least 70% agreement regarding the presence of transitional pattern was observed in 12 cases, with the rest of the cases showing a wide range of disagreement. Morphologic characteristics that favor transitional pattern over non-transitional include sheet-like growth of cohesive, plump, elongated epithelioid cells with well-defined cell borders and a tendency to transition into spindle cells. Our study defined precise morphologic criteria that may be used in the differential diagnosis between transitional pattern and other mesothelioma subtypes including sarcomatoid and epithelioid.
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