ArticleScientific reports2019
Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
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- Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes.Journal of internal medicine · 2025Review
- Metabolic alterations in the umbilical cord blood of pregnant women with uncontrolled type 2 diabetes mellitus: a matched-case comparative study in metabolomics.Diabetology & metabolic syndrome · 2025Article
- Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity.Critical care (London, England) · 2025Article
- Untargeted Lipidomic Profiling of Amniotic Fluid Reveals Dysregulated Lipid Metabolism in Healthy Normal-Weight Mothers with Fetal Macrosomia.Nutrients · 2024Article
- Fat burning capacity in a mixed macronutrient meal protocol does not reflect metabolic flexibility in women who are overweight or obese.medRxiv : the preprint server for health sciences · 2024Article
- Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance.Metabolites · 2024Article
- Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus.Cardiovascular diabetology · 2024Article
- Application of Clinical Blood Metabogram to Type 2 Diabetes Mellitus.Metabolites · 2024Article
- Exploring the Interactions between Obesity and Diabetes: Implications for Understanding Metabolic Dysregulation in a Saudi Arabian Adult Population.Journal of proteome research · 2024Article
- Several Metabolite Families Display Inflexibility during Glucose Challenge in Patients with Type 2 Diabetes: An Untargeted Metabolomics Study.Metabolites · 2023Article
- Application of Metabolomics and Traditional Chinese Medicine for Type 2 Diabetes Mellitus Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Metabolomic Selection in the Progression of Type 2 Diabetes Mellitus: A Genetic Algorithm Approach.Diagnostics (Basel, Switzerland) · 2022Article
- Specific triacylglycerol, diacylglycerol, and lyso-phosphatidylcholine species for the prediction of type 2 diabetes: a ~ 16-year prospective study in Chinese.Cardiovascular diabetology · 2022Article
- Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues.Cell reports. Medicine · 2022Article
- DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion.The EMBO journal · 2022Article
- Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus.Current diabetes reports · 2022Review
- MetaFetcheR: An R Package for Complete Mapping of Small-Compound Data.Metabolites · 2021Article
- Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.Nature communications · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes (T2D) mellitus is a complex metabolic disease commonly caused by insulin resistance in several tissues. We performed a matched two-dimensional metabolic screening in tissue samples from 43 multi-organ donors. The intra-individual analysis was assessed across five key metabolic tissues (serum, visceral adipose tissue, liver, pancreatic islets and skeletal muscle), and the inter-individual across three different groups reflecting T2D progression. We identified 92 metabolites differing significantly between non-diabetes and T2D subjects. In diabetes cases, carnitines were significantly higher in liver, while lysophosphatidylcholines were significantly lower in muscle and serum. We tracked the primary tissue of origin for multiple metabolites whose alterations were reflected in serum. An investigation of three major stages spanning from controls, to pre-diabetes and to overt T2D indicated that a subset of lysophosphatidylcholines was significantly lower in the muscle of pre-diabetes subjects. Moreover, glycodeoxycholic acid was significantly higher in liver of pre-diabetes subjects while additional increase in T2D was insignificant. We confirmed many previously reported findings and substantially expanded on them with altered markers for early and overt T2D. Overall, the analysis of this unique dataset can increase the understanding of the metabolic interplay between organs in the development of T2D.
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