ArticleScientific reports2019
Mechanical shear controls bacterial penetration in mucus.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Morphogenesis of bacterial colonies in liquid crystalline environments.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Stress-Induced Mechanical Memory in Respiratory Mucus: Anisotropy, Network Reorganization, and Directional Transport.bioRxiv : the preprint server for biology · 2026Article
- Article
- Unconventionally fast transport through sliding dynamics of rodlike particles in macromolecular networks.Nature communications · 2024Article
- Identification of a genomic cluster related to hypersecretion of intestinal mucus and mucinolytic activity of atypical enteropathogenicFrontiers in cellular and infection microbiology · 2024Article
- Single-cell magnetotaxis in mucus-mimicking polymeric solutions.Frontiers in microbiology · 2024Article
- Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions.Nature communications · 2023Article
- Native gastrointestinal mucus: Critical features and techniques for studying interactions with drugs, drug carriers, and bacteria.Advanced drug delivery reviews · 2023Review
- Viscoelasticity enhances collective motion of bacteria.PNAS nexus · 2023Article
- Motility of Different GastricMicroorganisms · 2023Review
- Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle.Frontiers in immunology · 2023Article
- Frustrated 'run and tumble' of swimmingInterface focus · 2022Article
- Mechanical Forces Govern Interactions of Host Cells with Intracellular Bacterial Pathogens.Microbiology and molecular biology reviews : MMBR · 2022Review
- Multiple functions of flagellar motility and chemotaxis in bacterial physiology.FEMS microbiology reviews · 2021Review
- Enhanced microscopic dynamics in mucus gels under a mechanical load in the linear viscoelastic regime.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Alkaline pH Increases Swimming Speed and Facilitates Mucus Penetration for Vibrio cholerae.Journal of bacteriology · 2021Article
- Home, sweet home: how mucus accommodates our microbiota.The FEBS journal · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucus plays crucial roles in higher organisms, from aiding fertilization to protecting the female reproductive tract. Here, we investigate how anisotropic organization of mucus affects bacterial motility. We demonstrate by cryo electron micrographs and elongated tracer particles imaging, that mucus anisotropy and heterogeneity depend on how mechanical stress is applied. In shallow mucus films, we observe bacteria reversing their swimming direction without U-turns. During the forward motion, bacteria burrowed tunnels that last for several seconds and enable them to swim back faster, following the same track. We elucidate the physical mechanism of direction reversal by fluorescent visualization of the flagella: when the bacterial body is suddenly stopped by the mucus structure, the compression on the flagellar bundle causes buckling, disassembly and reorganization on the other side of the bacterium. Our results shed light into motility of bacteria in complex visco-elastic fluids and can provide clues in the propagation of bacteria-born diseases in mucus.
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Registered trials
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