Evidence map›Paper›PMID 31273088›Full record

Trial reportHaematologica2020

Eltrombopag for the treatment of inherited thrombocytopenias: a phase II clinical trial.

Carlo Zaninetti, Paolo Gresele, Antonella Bertomoro, Catherine Klersy, Erica De Candia, Dino Veneri, Serena Barozzi, Tiziana Fierro, Maria Adele Alberelli, Valeria Musella and 4 more

Open access · goldAbstract readClinical Trial, Phase II
In one paragraph

Trial report in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
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  16. Frontiers in pediatrics · 2025
    Article
  17. Article
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  19. Research and practice in thrombosis and haemostasis · 2024
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Carlo ZaninettiDepartment of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia.
Paolo GreseleDepartment of Medicine, University of Perugia, Perugia.
Antonella BertomoroDepartment of Medicine, University of Padova, Padova.
Catherine KlersyService of Clinical Epidemiology & Biometry, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia.
Erica De CandiaIRCCS Policlinico Universitario A. Gemelli Foundation, Roma.
Dino VeneriDepartment of Medicine, Section of Hematology, University of Verona, Verona.
Serena BarozziDepartment of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia.
Tiziana FierroDepartment of Medicine, University of Perugia, Perugia.
Maria Adele AlberelliIRCCS Policlinico Universitario A. Gemelli Foundation, Roma.
Valeria MusellaService of Clinical Epidemiology & Biometry, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia.
Patrizia NorisDepartment of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia.
Fabrizio FabrisDepartment of Medicine, University of Padova, Padova.
Carlo L BalduiniDepartment of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia.
Alessandro PecciDepartment of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia alessandro.pecci@unipv.it.
University of Pavia · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Padua · ITUniversity of Perugia · ITAgostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with inherited thrombocytopenias often require platelet transfusions to raise their platelet count before surgery or other invasive procedures; moreover, subjects with clinically significant spontaneous bleeding may benefit from an enduring improvement of thrombocytopenia. The hypothesis that thrombopoietin-mimetics can increase platelet count in inherited thrombocytopenias is appealing, but evidence is scarce. We conducted a prospective, phase II clinical trial to investigate the efficacy of the oral thrombopoietin-mimetic eltrombopag in different forms of inherited thrombocytopenia. We enrolled 24 patients affected by

Indexed as

HydrazinesThrombocytopeniaBenzoatesHumansProspective StudiesPyrazolesBenzoateseltrombopagHydrazinesPyrazoles

Identifiers

PMID31273088
PMCPMC7049343
OpenAlexW2954041245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.