ArticleAJNR. American journal of neuroradiology2019
Human Parechovirus Meningoencephalitis: Neuroimaging in the Era of Polymerase Chain Reaction-Based Testing.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Neurodevelopmental Outcomes in Children with Neonatal Parechovirus CNS Infections.Pathogens (Basel, Switzerland) · 2025Article
- Examining Clinical Features and Severe Neurologic Disease of Parechovirus Infection in Young Infants: A Multistate Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Emergence of a New Pathogen: A Retrospective Study of HPeV-5 Central Nervous System Disease in Alberta, Canada.Viruses · 2024Article
- Clinical course and peculiarities of Parechovirus and Enterovirus central nervous system infections in newborns: a single-center experience.European journal of pediatrics · 2024Article
- Review
- Human Parechovirus (HPeV) infections: clinical presentations, patterns, and evolution of neonatal brain injury.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Human parechovirus meningitis in children: state of the art.Italian journal of pediatrics · 2023Review
- Human parechovirus encephalitis in infants: a retrospective single-center study (2017-2022).European journal of pediatrics · 2023Article
- Human parechovirus meningoencephalitis.SA journal of radiology · 2023Article
- Magnetic resonance imaging patterns of paediatric brain infections: a pictorial review based on the Western Australian experience.Insights into imaging · 2022Review
- Expert consensus on the clinical practice of neonatal brain magnetic resonance imaging.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Longitudinal brain magnetic resonance imaging of children with perinatal Chikungunya encephalitis.The neuroradiology journal · 2020Article
- Non-congenital viral infections of the central nervous system: from the immunocompetent to the immunocompromised child.Pediatric radiology · 2020Review
- Brain MR Imaging of Patients with Perinatal Chikungunya Virus Infection.AJNR. American journal of neuroradiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human parechovirus infection is an increasingly recognized cause of neonatal meningoencephalitis. We describe characteristic clinical features and brain MR imaging abnormalities of human parechovirus meningoencephalitis in 6 infants. When corroborated by increasingly available polymerase chain reaction-based testing of the CSF, the distinctive MR imaging appearance may yield a specific diagnosis that obviates costly and time-consuming further clinical evaluation. In our study, infants with human parechovirus presented in the first 35 days of life with seizures, irritability, and sepsis. MR imaging consistently demonstrated low diffusivity within the thalami, corpus callosum, and subcortical white matter with a frontoparietal predominance. T1 and T2 shortening connoting white matter injury along the deep medullary veins suggests venous ischemia as an alternative potential pathogenetic mechanism to direct neuroaxonal injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.