ArticleJACC. Cardiovascular interventions2019
Impact of Leaflet Laceration on Transcatheter Aortic Valve-in-Valve Washout: BASILICA to Solve Neosinus and Sinus Stasis.
Article in JACC. Cardiovascular interventions, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Neosinus and Valve Thrombosis After Transcatheter Aortic Valve Replacement.Journal of the American Heart Association · 2026Pooled it
- Current Evidence, Emerging Evidence, and Decision-Making: An Algorithm for Leaflet Modification Procedures.JACC. Cardiovascular interventions · 2026Review
- Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data.Journal of cardiovascular translational research · 2025Article
- Transcatheter Aortic Valve Implantation and Replacement: The Latest Advances and Prospects.Journal of clinical medicine · 2025Review
- Benchtop Flow Stasis Quantification: In Vitro Methods and In Vivo Possibilities.Cardiovascular engineering and technology · 2024Article
- Aortic Valve-in-Valve Procedures: Challenges and Future Directions.Journal of clinical medicine · 2024Review
- Thrombosis of Bioprosthetic Aortic Valve: Is the Entire Arsenal Deployed?Reviews in cardiovascular medicine · 2024Review
- Long-Term Outcomes of Transcatheter vs Surgical Aortic Valve Replacement: Meta-analysis of Randomized Trials.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Review
- Role of leaflet modification in TAVI: to prevent coronary obstruction only or potentially a routine practice?EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Effect of Ascending Aortic Curvature on Flow in the Sinus and Neo-sinus Following TAVR: A Patient-Specific Study.Annals of biomedical engineering · 2024Article
- Effect of Native Aortic Leaflet Geometry Modification on Transcatheter Aortic Valve Neo-sinus and Aortic Sinus Flow: An In-vitro Study.Cardiovascular engineering and technology · 2023Article
- Comparison of performance of self-expanding and balloon-expandable transcatheter aortic valves.JTCVS open · 2022Article
- Multiple MitraClips: The balancing act between pressure gradient and regurgitation.The Journal of thoracic and cardiovascular surgery · 2022Article
- Article
- Valve-in-valve Transcatheter Aortic Valve Replacement for Failed Surgical Valves and Adjunctive Therapies.US cardiology · 2022Review
- Predictive Model for Thrombus Formation After Transcatheter Valve Replacement.Cardiovascular engineering and technology · 2021Article
- Transcatheter aortic valve thrombosis: a review of potential mechanisms.Journal of the Royal Society, Interface · 2021Review
- Atrial and ventricular flows across a transcatheter mitral valve.Interactive cardiovascular and thoracic surgery · 2021Article
- BASILICA Trial: One-Year Outcomes of Transcatheter Electrosurgical Leaflet Laceration to Prevent TAVR Coronary Obstruction.Circulation. Cardiovascular interventions · 2021Article
- Calcific Aortic Stenosis-A Review on Acquired Mechanisms of the Disease and Treatments.Frontiers in cardiovascular medicine · 2021Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThe aim of this study was to evaluate any potential leaflet washout benefits after bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction during TAVR (BASILICA) in transcatheter valve-in-valve (ViV) in the context of leaflet thrombosis.
backgroundLeaflet thrombosis after transcatheter aortic valve replacement is secondary to flow stasis in both the sinus and neosinus. Strategies to improve washout and ameliorate neosinus and sinus flow velocities may have the potential to mitigate the occurrence of clinical and subclinical leaflet thrombosis.
methodsA 23-mm Edwards SAPIEN 3 and a 26-mm Medtronic Evolut were deployed in a 23-mm transparent surgical aortic valve model before and after leaflet laceration. The valves were placed in the aortic position of a pulse duplicator flow loop. Particle image velocimetry was performed to quantify sinus flow hemodynamic status. A tracing fluorescent dye was injected to evaluate the number of cycles to washout in both regions of interest.
resultsThe leaflet laceration procedure led to an increase in the velocities in the sinus and the neosinus by 50% for Evolut ViV and 61.9% for SAPIEN 3 ViV. In addition, leaflet laceration led to a reduction in overall cycles to washout in the neosinus by at least 56% with the Evolut and 54.5% with the SAPIEN 3 and in the sinus by at least 16.7% with the Evolut and 60.8% with the SAPIEN.
conclusionsLeaflet laceration using a BASILICA-type approach may hold the potential to mitigate neosinus and sinus flow stasis. Controlled in vivo trials are necessary to establish the potential benefit of BASILICA to reduce the occurrence of leaflet thrombosis.
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