ArticleRespiratory research2019
Prevalence of and risk factors for pulmonary complications after curative resection in otherwise healthy elderly patients with early stage lung cancer.
Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- Dexmedetomidine for prevention of postoperative pulmonary complications in patients after oral and maxillofacial surgery with fibular free flap reconstruction:a prospective, double-blind, randomized, placebo-controlled trial.BMC anesthesiology · 2020Trial
- Automated quantification of interstitial lung abnormalities and emphysema on computed tomography: a predictive marker for postoperative pulmonary complications after esophagectomy.Esophagus : official journal of the Japan Esophageal Society · 2026Article
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- A prehabilitation-enhanced nomogram for predicting early pulmonary recovery failure after lung tumor surgery: development and multicenter validation.Frontiers in medicine · 2026Article
- Is Chest Wall Resection Safe in Geriatric Non-Small Cell Lung Cancer?The clinical respiratory journal · 2025Article
- Prognostic impacts of interstitial lung abnormalities on outcomes following resection for lung cancer.BMJ open respiratory research · 2025Article
- A Comprehensive Review of Interstitial Lung Abnormalities.Respirology (Carlton, Vic.) · 2025Review
- Effectiveness of bronchoscopy-assisted postoperative respiratory management in patients with lung cancer and impaired cough strength: a retrospective cohort study.Annals of medicine and surgery (2012) · 2025Article
- Current perspectives on interstitial lung abnormalities.The Korean journal of internal medicine · 2025Review
- Risk Factors for Postoperative Pulmonary Complications in Patients Undergoing Thoracotomy for Indications Other than Primary Lung Cancer Resection: A Multicenter Retrospective Cohort Study from the German Thorax Registry.Journal of clinical medicine · 2025Article
- Incidence and risk factors of pulmonary complications after lung cancer surgery: A systematic review and meta-analysis.Heliyon · 2024Article
- Is a high preoperative HbA1c level a risk factor for postoperative complications in patients with non-small-cell lung cancer?Journal of cardiothoracic surgery · 2024Article
- Automated CT quantification of interstitial lung abnormality in patients with resectable stage I non-small cell lung cancer: Prognostic significance.Thoracic cancer · 2024Article
- Enhanced recovery after surgery in elderly patients with non-small cell lung cancer who underwent video-assisted thoracic surgery.World journal of clinical cases · 2024Article
- Predicting postoperative lung function using ventilation SPECT/CT in patients with lung cancer.Journal of thoracic disease · 2024Article
- Article
- Predictors associated with Clavien-Dindo complications in lung cancer surgery: A retrospective cohort study.PloS one · 2024Article
- Pre-Existing Interstitial Lung Abnormalities in Patients with Head and Neck Squamous Cell Carcinoma and Their Follow Up after Therapy.Diagnostics (Basel, Switzerland) · 2023Article
- Review
- Prognostic value of the early lung ultrasound B-line score for postoperative pulmonary insufficiency in patients undergoing thoracic surgery: an observational study.European journal of medical research · 2023Observational
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveThe prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying lung diseases. We aimed to determine the prevalence of and risk factors for postoperative pulmonary complications (PPCs) in healthy elderly patients with non-small cell lung cancer (NSCLC) to select optimal candidates for surgical resection in this subpopulation.
methodsWe included 488 patients older than 70 years with normal spirometry results who underwent curative resection for NSCLC (stage IA-IIB) between 2012 and 2016.
resultsThe median (interquartile range) age of our cohort was 73 (71-76) years. Fifty-two patients (10.7%) had PPCs. Severe PPCs like acute respiratory distress syndrome, pneumonia, and respiratory failure had prevalences of 3.7, 3.7, and 1.4%, respectively. Compared to patients without PPCs, those with PPCs were more likely to be male and current smokers; have a lower body mass index (BMI), higher American Society of Anesthesiologists (ASA) classification, more interstitial lung abnormalities (ILAs), and higher emphysema index on computed tomography (CT); and have undergone pneumonectomy or bilobectomy (all p < 0.05). On multivariate analysis, ASA classification ≥3, lower BMI, ILA, and extent of resection were independently associated with PPC risk. The short-term all-cause mortality was significantly higher in patients with PPCs.
conclusionsCurative resection for NSCLC in healthy elderly patients appeared feasible with 10% PPCs. ASA classification ≥3, lower BMI, presence of ILA on CT, and larger extent of resection are predictors of PPC development, which guide treatment decision-making in these patients.
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