ArticleBMC gastroenterology2019
Strong association between metabolically-abnormal obesity and gallstone disease in adults under 50 years.
Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Association between albumin-bilirubin score and gallstones: exploring the potential mediating role of body mass index based on NHANES 2017-2020.Internal and emergency medicine · 2026Article
- Association of sleep disorder with increased risk of gallstone disease in adults in the United States: A cross-sectional study of the National Health and Nutrition Examination Survey (2017-2020).The Journal of international medical research · 2026Article
- The effectiveness of two-step percutaneous transhepatic choledochoscopic lithotripsy for hepatolithiasis: a retrospective study.Updates in surgery · 2026Article
- Positive association between cardiometabolic index and gallstones, with greater impact on women and those younger than 50 years: the NHANES 2017-2020 cross-sectional study.BMC public health · 2025Article
- Association between platelet-to-high-density lipoprotein cholesterol ratio and gallstone prevalence in the American adult population: a cross-sectional study analysis.BMC gastroenterology · 2025Article
- Association between fibrosis-4 index (FIB-4) and gallstones: an analysis of the NHANES 2017-2020 cross-sectional study.BMC gastroenterology · 2025Article
- Higher relative fat mass was associated with a higher prevalence of gallstones in US adults.BMC gastroenterology · 2025Article
- Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017-2020.Preventive medicine reports · 2025Article
- Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones.Scientific reports · 2025Article
- Association between relative fat mass and gallstones: a cross-sectional study based on NHANES 2017-2020.Frontiers in nutrition · 2025Article
- Association of arm circumference with the prevalence of gallstones in United States adults: a retrospective analysis on US National Health and Nutrition Examination Survey.Frontiers in medicine · 2025Article
- How preoperative upper gastrointestinal investigations affect the management of bariatric patients: results of a cohort study of 897 patients.Surgical endoscopy · 2025Article
- High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES.Frontiers in medicine · 2025Article
- Ultraprocessed food consumption and risk of gallstone disease: analysis of 3 prospective cohorts.The American journal of clinical nutrition · 2024Article
- Association between triglyceride-glucose index and gallstones: a cross-sectional study.Scientific reports · 2024Article
- Relationship of triglyceride-glucose index to gallstone prevalence and age at first gallstone surgery in American adults.Scientific reports · 2024Article
- PMHeliyon · 2024Article
- Comprehensive analysis of differential long non-coding RNA and messenger RNA expression in cholelithiasis using high-throughput sequencing and bioinformatics.Frontiers in genetics · 2024Article
- The role of metabolic factors in the association between obesity and cholelithiasis: A two-step, two-sample multivariable mendelian randomization study.Clinics (Sao Paulo, Brazil) · 2024Article
- Elevated TyG index associated with increased prevalence of gallstones in a United States cross-sectional study.Frontiers in public health · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundAge, obesity, and metabolic syndrome are known risk factors for gallstones; however, the combined impact of these different risk factors on gallstone formation has not yet been examined.
methodsThis retrospective, cross-sectional study involved 3190 participants, including 207 participants (6.5%) with gallstones and 986 (30.9%) with metabolic syndrome. Participants were divided into four phenotypes according to metabolic syndrome and obesity status: 1378 participants were metabolically healthy and non-obese (MHNO); 826 were metabolically healthy but obese (MHO); 185 were metabolically abnormal but not obese (MANO); and 801 participants were metabolically abnormal and obese (MAO).
resultsThe MAO and MANO phenotypes had more gallstones than the MHO and MHNO phenotypes, regardless of age (< 50 or ≥ 50 years old). Multivariate analyses showed that phenotype was an independent risk factor for gallstones in participants < 50 years old (odds ratio (OR) = 1.73, 95% confidence interval (CI) = 1.32-2.28). Younger participants also had a higher risk of gallstones in the MAO (OR = 5.41, 95% CI = 2.31-12.66), MANO (OR = 3.18, 95% CI = 0.86-11.75), and MHO (OR = 2.17, 95% CI = 0.90-5.22) phenotypes than the MHNO phenotype.
conclusionsOur retrospective results demonstrate an increased association of gallstones in younger people (< 50 years old) with metabolic syndrome and obesity.
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