Observational studyBMC cardiovascular disorders2019
High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study.
Observational study in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- The ratio of serum glucose to potassium is associated with poor prognosis in patients with severe acute myocardial infarction.Scientific reports · 2025Article
- The association between stress hyperglycemia ratio and 1-year outcomes in patients with acute myocardial infarction: a retrospective large sample cohort study.Frontiers in endocrinology · 2025Article
- Acute Hyperglycemia and Its Impact on Mortality of Acute Coronary Syndrome Patients: A Systematic Review.Cureus · 2024Review
- Insulin resistance in Takotsubo syndrome.ESC heart failure · 2024Article
- The global burden of ischemic heart disease attributed to high fasting plasma glucose: Data from 1990 to 2019.Heliyon · 2024Article
- Relationship between stress hyperglycaemic ratio and incidence of in-hospital cardiac arrest in patients with acute coronary syndrome: a retrospective cohort study.Cardiovascular diabetology · 2024Article
- Serum glucose-potassium ratio predicts inhospital mortality in patients admitted to coronary care unit.Revista da Associacao Medica Brasileira (1992) · 2024Observational
- Serum oxidative stress factors predict myocardial ischemia reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction and type 2 diabetes mellitus.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2023Article
- Predictors of Carbohydrate Metabolism Disorders and Lethal Outcome in Patients after Myocardial Infarction: A Place of Glucose Level.Journal of personalized medicine · 2023Article
- Short and long-term prognosis of admission hyperglycemia in patients with and without diabetes after acute myocardial infarction: a retrospective cohort study.Cardiovascular diabetology · 2022Article
- SRPX2 attenuated oxygen-glucose deprivation and reperfusion-induced injury in cardiomyocytes via alleviating endoplasmic reticulum stress-induced apoptosis through targeting PI3K/Akt/mTOR axis.Open life sciences · 2022Article
- Stress and the "extended" autonomic system.Autonomic neuroscience : basic & clinical · 2021Review
- Admission hyperglycemia and all-cause mortality in diabetic and non-diabetic patients with acute myocardial infarction: a tertiary center analysis.Internal and emergency medicine · 2021Article
- Article
- Effects of Stress Hyperglycemia on Short-Term Prognosis of Patients Without Diabetes Mellitus in Coronary Care Unit.Frontiers in cardiovascular medicine · 2021Article
- Effect of Admission Hyperglycemia on Short-Term Prognosis of Patients with Non-ST Elevation Acute Coronary Syndrome without Diabetes Mellitus.Journal of diabetes research · 2021Article
- The extended autonomic system, dyshomeostasis, and COVID-19.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPatients with acute myocardial infarction (AMI) often accompanied by admission hyperglycemia, which usually predicts a poor clinical outcomes for non-diabetes mellitus. Appropriate cut-point to identify high risk individuals in these patients remains controversial.
methodsOne thousand six hundred ninety-eight non-diabetes AMI patients in this retrospective study were divided into 3 groups according to admission glucose levels (euglycemia group≤140 mg/dL, moderate hyperglycemia group 141-179 mg/dL, severe hyperglycemia group≥180 mg/dL). The primary endpoint of this study was all-cause in-hospital mortality rate. In-hospital motality related risk factors was analyzed by multivariate binary logistic regression analyses.
resultsAll myocardial necrosis markers and Log NT-proBNP in severe hyperglycemia group were significantly higher than those in the other 2 groups. Logistic regression showed that independent predictors of the in-hospital mortality rate in non-diabetic patients with AMI were age (OR = 1.057, 95% CI 1.024-1.091, P < 0.001), logarithm of the N-terminal pro-brain natriuretic peptide (OR = 7.697, 95% CI 3.810-15.550, P < 0.001), insufficient myocardial reperfusion (OR = 7.654, 95% CI 2.109-27.779, P < 0.001), percutaneous coronary intervention (OR = 0.221, 95% CI 0.108-0.452, P < 0.001) and admission glucose (as categorical variable). Patients with moderate hyperglycemia (OR = 1.186, 95% CI 0.585-2.408, P = .636) and severe hyperglycemia (OR = 4.595, 95% CI 1.942-10.873, P = 0.001) had a higher all-cause in-hospital mortality rate compared with those with euglycemia after AMI in non-diabetic patients.
conclusionsThe all-cause in-hospital mortality risk increases remarkably as admission glucose levels elevated in non-diabetic patients with AMI, especially in patients with admission glucose levels ≥180 mg/dL. Severe admission hyperglycemia could be regarded as prospective high-risk marker for non-diabetic AMI patients.
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