Evidence map›Paper›PMID 31272312›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, "M-type") K

Fabio A Vigil, Eda Bozdemir, Vladislav Bugay, Sang H Chun, MaryAnn Hobbs, Isamar Sanchez, Shayne D Hastings, Rafael J Veraza, Deborah M Holstein, Shane M Sprague and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Acute Treatment with the M-Channel (KNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  12. Article
  13. Article
  14. Selective block of adenosine ABritish journal of pharmacology · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Neuroprotective Roles of the Adenosine ANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Article
  19. Microvascular changes associated with epilepsy: A narrative review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Review
  20. The KNeuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Fabio A VigilDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
Eda BozdemirDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
Vladislav BugayDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
Sang H ChunDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
MaryAnn HobbsDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
Isamar SanchezDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
Shayne D HastingsDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
Rafael J VerazaDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
Deborah M HolsteinDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
Shane M SpragueDepartment of Neurosurgery, University of Texas Health San Antonio, San Antonio, TX, USA.
Chase M CarverDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
Jose E CavazosDepartment of Neurology, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0001-5777-2608
Robert BrennerDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
James D LechleiterDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
Mark S ShapiroDepartment of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, USA.
The University of Texas Health Science Center at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
ROLE OF CASPASE-2 IN OSTEOCOLAST APOPTOSIS AGE-EePENDENT OSTEOPOROSISP01AG019316 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HERMAN, BRIAN A. · 2001 to 2011
$11.3M
Targeting specific interactions between A-kinase Anchoring Proteins (AKAPs) and ion channels with cell-permeant peptides as a novel mode of therapeutic intervention against pain disordersR01NS094461 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2015 to 2019
$2.0M
Mechanism and functional role of AKAP79/150 in M current control and excitabilityR01NS065138 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2009 to 2010
$788k
NCI NIH HHS P30 CA054174NIA NIH HHS P01 AG019316NINDS NIH HHS R01 NS065138NINDS NIH HHS R01 NS094461
6 · The paper itself

Abstract

Nearly three million people in the USA suffer traumatic brain injury (TBI) yearly; however, there are no pre- or post-TBI treatment options available. KCNQ2-5 voltage-gated K

Indexed as

AnimalsAnticonvulsantsBrain Injuries, TraumaticCarbamatesKCNQ Potassium ChannelsMiceMice, Inbred C57BLNeuronsPhenylenediaminesAnticonvulsantsCarbamatesezogabineKCNQ Potassium ChannelsPhenylenediaminesCell deathK+ channelsKCNQseizurestraumatic brain injury

Identifiers

PMID31272312
PMCPMC7238379
OpenAlexW2956066042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.