Evidence map›Paper›PMID 31272099›Full record

ArticleJournal of vascular research2019

Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans.

Gurneet S Sangha, Albert Busch, Andrea Acuna, Alycia G Berman, Evan H Phillips, Matthias Trenner, Hans-Henning Eckstein, Lars Maegdefessel, Craig J Goergen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mechanosignals in abdominal aortic aneurysms.Frontiers in cardiovascular medicine · 2022
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Gurneet S SanghaPurdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana, USA.
Albert BuschTechnical University Munich, Department for Vascular and Endovascular Surgery, Munich Aortic Center, Klinikum rechts der Isar, Munich, Germany.
Andrea AcunaPurdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana, USA.
Alycia G BermanPurdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana, USA.
Evan H PhillipsPurdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana, USA.
Matthias TrennerTechnical University Munich, Department for Vascular and Endovascular Surgery, Munich Aortic Center, Klinikum rechts der Isar, Munich, Germany.
Hans-Henning EcksteinTechnical University Munich, Department for Vascular and Endovascular Surgery, Munich Aortic Center, Klinikum rechts der Isar, Munich, Germany.
Lars MaegdefesselTechnical University Munich, Department for Vascular and Endovascular Surgery, Munich Aortic Center, Klinikum rechts der Isar, Munich, Germany.
Craig J GoergenPurdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana, USA, cgoergen@purdue.edu.
Purdue University West Lafayette · USTUM Klinikum · DE

Funding

Interdisciplinary Bioengineering Training in Diabetes ResearchT32DK101001 · NIDDK · PURDUE UNIVERSITY · PI EVANS-MOLINA, CARMELLA, VOYTIK-HARBIN, SHERRY L · 2013 to 2022
$1.6M
American Heart Association-American Stroke Association 14SDG18220010NIDDK NIH HHS T32 DK101001
6 · The paper itself

Abstract

Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to longitudinally study mice that underwent standard porcine pancreatic elastase (PPE) infusion (n = 5), and PPE infusion with modified 20% iliac artery stenosis in the left (n = 4) and right (n = 5) iliac arteries. Human AAA computed tomography images were obtained from patients with normal (n = 9) or stenosed left (n = 2), right (n = 1), and bilateral (n = 1) iliac arteries. We observed rapid early growth and rightward expansion (8/9 mice) in the modified PPE groups (p < 0.05), leading to slightly larger and asymmetric AAAs compared to the standard PPE group. Further examination showed a significant increase in TGFβ1 (p < 0.05) and cellular infiltration (p < 0.05) in the modified PPE group versus standard PPE mice. Congruent, yet variable, observations were made in human AAA patients with reduced iliac outflow compared to those with normal iliac outflow. Our results suggest that arterial stenosis at the time of aneurysm induction leads to faster AAA growth with aneurysm asymmetry and increased vascular inflammation after 8 weeks, indicating that moderate iliac stenosis may have upstream effects on AAA progression.

Indexed as

Iliac ArteryAnimalsAortic Aneurysm, AbdominalArterial Occlusive DiseasesBlood Flow VelocityCase-Control StudiesConstriction, PathologicDisease Models, AnimalDisease ProgressionHumansInterleukin-6MaleMice, Inbred C57BLPancreatic ElastaseRegional Blood FlowRisk FactorsInterleukin-6interleukin-6, mousePancreatic ElastaseTgfb1 protein, mouseTransforming Growth Factor beta1Vascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseAneurysmAsymmetryIliac arteryMurine

Identifiers

PMID31272099
PMCPMC6819217
OpenAlexW2955293896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.