ArticleChemosphere2019
Quantification of 16 urinary biomarkers of exposure to flame retardants, plasticizers, and organophosphate insecticides for biomonitoring studies.
Article in Chemosphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- A systematic review of organophosphorus pesticides detection in biological matrices.Forensic science, medicine, and pathology · 2025Pooled it
- A randomized controlled trial of a housing intervention to reduce endocrine disrupting chemical exposures in children.Environment international · 2024Trial
- Article
- Urinary biomarkers of PAHs, VOCs, OPEs, and metal(loid)s in firefighters responding in the wildland urban interface (WUI).International journal of hygiene and environmental health · 2026Article
- Relationship of prenatal pesticide exposures with prenatal ultrasound and birth growth measures among offspring of women living with HIV.International journal of hygiene and environmental health · 2026Article
- Identifying associations and key early life exposure windows for organophosphate esters and adolescent brain morphometry in the HOME study.Environmental research · 2026Article
- Association between gestational and childhood exposures to organophosphate esters and social skill, problem behavior among adolescents.Environmental research · 2026Article
- Organophosphate pesticide DEDT promotes diabetic retinopathy progression via AMPK/Nrf2/HO-1 pathway.Scientific reports · 2026Article
- Maternal serum polybrominated diphenyl ether concentrations during pregnancy and adolescent bone mineral density at age 12 years.International journal of hygiene and environmental health · 2026Article
- Association between organophosphorus flame retardant exposure and chronic kidney disease in U.S. adults: NHANES data from 2011 to 2016.European journal of medical research · 2026Article
- Determinants of urinary dialkyl phosphate metabolites in midlife women: the Study of Women's Health Across the Nation Multi-Pollutant Study (SWAN-MPS).Journal of exposure science & environmental epidemiology · 2025Article
- Prenatal and postnatal exposure to organophosphate esters and replacement flame retardant mixtures and childhood respiratory outcomes.Environmental research · 2025Article
- Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers.Frontiers in toxicology · 2025Article
- Gestational organophosphate esters (OPEs) and executive function in adolescence: The HOME Study.Environmental research · 2024Article
- Exposure to organophosphate ester flame retardants and plasticizers and associations with preeclampsia and blood pressure in pregnancy.Environmental research · 2024Article
- Metabolomics and proteomics in occupational medicine: a comprehensive systematic review.Journal of occupational medicine and toxicology (London, England) · 2024Review
- Review
- Urinary Concentrations of Organophosphate Flame-Retardant Metabolites in the US Population.JAMA network open · 2024Article
- Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes.Nutrition & diabetes · 2024Article
- Organophosphate Ester Flame Retardants and Plasticizers in Relation to Fetal Growth in the LIFECODES Fetal Growth Study.Environmental health perspectives · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chlorinated alkyl and non-chlorinated aryl organophosphate flame retardants (OPFRs) and some brominated flame retardants (FR) were introduced as replacements for polybrominated diphenyl ethers (PBDEs) after PBDEs phase-out in 2004 and 2013. Organophosphorous (OP) insecticides are mainly used in agricultural settings since the Food Quality Protection Act of 1996 phased-out most residential uses of OP insecticides in the United States. Urinary metabolites of FRs and OPs are known exposure biomarkers to FRs and OP insecticides, respectively. For large population-based studies, concurrent quantification of these metabolites using a small urine volume is desirable, but until now was not possible. We developed an analytical approach to quantify in 0.2 mL urine 10 FRs and six OP insecticide metabolites: diphenyl phosphate, bis(1,3-dichloro-2-propyl) phosphate, bis(1-chloro-2-propyl) phosphate, bis(2-chloroethyl) phosphate, dicresyl phosphates, dibutyl phosphate, dibenzyl phosphate, 2,3,4,5-tetrabromobenzoic acid, 2-((isopropyl)phenyl)phenyl phosphate, 4-((tert-butyl)phenyl)phenyl phosphate, dimethyl phosphate, diethyl phosphate, dimethyl thiophosphate, dimethyl dithiophosphate, diethyl thiophosphate, and diethyl dithiophosphate. The method relies on enzymatic deconjugation, automated off-line solid phase extraction, high-performance liquid chromatography, and isotope dilution tandem mass spectrometry. Detection limits ranged from 0.05 to 0.5 ng mL
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Registered trials
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