Evidence map›Paper›PMID 31271833›Full record

ArticlePhysiology & behavior2019

Immunomodulatory T cell death associated gene-8 (TDAG8) receptor in depression-associated behaviors.

Katherine M J McMurray, Lauren Larke Vollmer, Rebecca Ahlbrand, Joshua Thomas, Andrew Winter, Ian P Lewkowich, Renu Sah

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Sex differences in responses to panicogen COFrontiers in cellular neuroscience · 2026
    Article
  2. Review
  3. Physiological relevance of proton-activated GPCRs.Pflugers Archiv : European journal of physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Katherine M J McMurrayDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: mcmurrkm@uc.edu.
Lauren Larke VollmerDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rebecca AhlbrandDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Joshua ThomasDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Andrew WinterDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Neuroscience Graduate Program, University of Cincinnati, Medical Sciences Building, Room 1058B, 231 Albert Sabin Way, Cincinnati, OH 45237, USA.
Ian P LewkowichDivision of Immunobiology, Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.
Renu SahDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Neuroscience Graduate Program, University of Cincinnati, Medical Sciences Building, Room 1058B, 231 Albert Sabin Way, Cincinnati, OH 45237, USA; VA Medical Center, Cincinnati, OH 45237, USA.
University of Cincinnati Medical Center · USCincinnati Children's Hospital Medical Center · USSabin Vaccine Institute · US

Funding

Psychology Training in Alcohol Research (PTAR)T32AA007455 · NIAAA · UNIVERSITY OF WASHINGTON · PI MARY E. LARIMER · 1985 to 2026
$11.4M
Training Program in Neuroendocrinology of HomeostasisT32DK059803 · NIDDK · UNIVERSITY OF CINCINNATI · PI WOODS, STEPHEN C · 2001 to 2017
$2.8M
Acid-sensing and PanicR01MH093362 · NIMH · UNIVERSITY OF CINCINNATI · PI SAH, RENU · 2012 to 2016
$1.9M
Neurovascular signaling and associated forebrain circuits in PTSDI01BX001075 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI SAH, RENU · 2011 to 2025
–
BLRD VA I01 BX001075NIAAA NIH HHS T32 AA007455NIDDK NIH HHS T32 DK059803NIMH NIH HHS R01 MH093362
6 · The paper itself

Abstract

Converging evidence supports neuroimmune factors in depression psychopathology. We previously reported reduced depression-like behavior in immunomodulatory G-protein-coupled receptor, T cell death-associated gene-8 (TDAG8) deficient mice. Here, we expand on those findings by investigating depression- and anxiety-associated behaviors, and cytokine profiles in TDAG8-deficient mice. TDAG8-deficiency reduced depression- and anxiety-associated behaviors in the forced swim test (FST), open-field test and elevated zero maze. Interestingly, cytokine expression, particularly IL-6, was attenuated within hippocampus and spleen in TDAG8-deficient mice following the FST. There were no differences in immune-cell frequencies. Collectively, these data suggest a contributory role of TDAG8 in neuroimmune regulation and depression-associated physiology.

Indexed as

Behavior, AnimalAnimalsAnxietyCell DeathCytokinesDepressionHippocampusInterleukin-6MiceMice, Inbred BALB CMice, KnockoutReceptors, G-Protein-CoupledSpleenSwimmingT-LymphocytesCytokinesGPR65 protein, mouseInterleukin-6interleukin-6, mouseReceptors, G-Protein-CoupledAnxietyCytokineDepressionIL-6MemoryTDAG8

Identifiers

PMID31271833
PMCPMC6701469
OpenAlexW2953830193

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.