Evidence map›Paper›PMID 31271802›Full record

SynthesisNeuroscience and biobehavioral reviews2019

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead.

Hamed Ekhtiari, Hosna Tavakoli, Giovanni Addolorato, Chris Baeken, Antonello Bonci, Salvatore Campanella, Luis Castelo-Branco, Gaëlle Challet-Bouju, Vincent P Clark, Eric Claus and 66 more

2 registry-linked trialsOpen access · greenAbstract readSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 156 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 10 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04864080 narecruitingnot on this mapstarted 2022, after this paper: background citation

Transdiagnostic Cognitive Biomarkers

TypeinterventionalSponsorUniversity of MinnesotaRan2022 to 2027Enrolled45ConditionsPain, DepressionArmsComputer game/task, Health surveys online
NCT06346028 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

A Pragmatic Feasibility Trial on the Implementation of Transcranial Magnetic Stimulation for Smoking Cessation

TypeinterventionalSponsorCentre for Addiction and Mental HealthRan2024 to 2028Enrolled40ConditionsSmokingArmsBrainsway H4 deep rTMS coil and Brainsway stimulator system
3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 10 syntheses or guidelines pooled it, 293 citations in OpenAlex.

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  5. Digitalized transcranial electrical stimulation: A consensus statement.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
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  9. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

76 authors at 20 institutions in 17 countries.

Hamed EkhtiariLaureate Institute for Brain Research, USA. Electronic address: hekhtiari@laureateinstitute.org.
Hosna TavakoliInstitute for Cognitive Science Studies (ICSS), Iran; Iranian National Center for Addiction Studies (INCAS), Iran.
Giovanni AddoloratoAlcohol Use Disorder Unit, Division of Internal Medicine, Gastroenterology and Hepatology Unit, Catholic University of Rome, A. Gemelli Hospital, Rome, Italy; Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Chris BaekenDepartment of Psychiatry and Medical Psychology, University Hospital Ghent, Ghent, Belgium.
Antonello BonciIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Salvatore CampanellaUniversité Libre de Bruxelles (ULB), Belgium.
Luis Castelo-BrancoSpaulding Rehabilitation Hospital, Harvard Medical School, USA.
Gaëlle Challet-BoujuUniversity of Nantes, France.
Vincent P ClarkUniversity of New Mexico, USA; The Mind Research Network, USA.
Eric ClausThe Mind Research Network, USA.
Pinhas N DannonUniversity of Tel Aviv, Israel.
Alessandra Del FeliceUniversity of Padova, Department of Neuroscience, Padova, Italy; Padova Neuroscience Center (PNC), University of Padova, Padova, Italy.
Tess den UylUniversity of Amsterdam, The Netherlands.
Marco Diana'G. Minardi' Laboratory of Cognitive Neuroscience, Department of Chemistry and Pharmacy, University of Sassari, Italy.
Massimo di GiannantonioUniversity G.d'Annunzio of Chieti-Pescara, Italy.
John R FedotaNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Paul FitzgeraldMonash University, Australia.
Luigi GallimbertiNovella Fronda Foundation, Human Science and Brain Research, Padua, Italy.
Marie Grall-BronnecUniversity of Nantes, France.
Sarah C HerremansDepartment of Psychiatry and Medical Psychology, University Hospital Ghent, Ghent, Belgium.
Martin J HerrmannCenter of Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
Asif JamilLeibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.
Eman KhedrAssiut University Hospital, Egypt.
Christos KouimtsidisImperial College London, UK.
Karolina KozakUniversity of Toronto, Canada; Centre for Addiction and Mental Health (CAMH), Canada.
Evgeny KrupitskyV. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St.-Petersburg, Russia; St.-Petersburg First Pavlov State Medical University, Russia.
Claus LammDepartment of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Austria.
William V LechnerKent State University, USA.
Graziella MadeoIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Nastaran MalmirIranian National Center for Addiction Studies (INCAS), Iran.
Giovanni MartinottiUniversity G.d'Annunzio of Chieti-Pescara, Italy.
William M McDonaldDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Chiara MontemitroIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; University G.d'Annunzio of Chieti-Pescara, Italy.
Ester M Nakamura-PalaciosFederal University of Espírito Santo, Brazil.
Mohammad NasehiCognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Xavier NoëlUniversité Libre de Bruxelles (ULB), Belgium.
Masoud NosratabadiUniversity of Social Welfare and Rehabilitation Sciences, Iran.
Martin PaulusLaureate Institute for Brain Research, USA.
Mauro PettorrusoUniversity G.d'Annunzio of Chieti-Pescara, Italy.
Basant PradhanCooper University Hospital, USA.
Samir K PraharajKasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Haley RaffertySpaulding Rehabilitation Hospital, Harvard Medical School, USA.
Gregory SahlemMedical University of South Carolina (MUSC), USA.
Betty Jo SalmeronIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Anne SauvagetLaboratory «Movement, Interactions, Performance» (E.A. 4334), University of Nantes, 25 Bis Boulevard Guy Mollet, BP 72206, 44322, Nantes Cedex 3, France; CHU de Nantes Addictology and Liaison Psychiatry Department, University Hospital Nantes, Nantes Cedex 3, France.
Renée S SchluterLaureate Institute for Brain Research, USA; Institute for Cognitive Science Studies (ICSS), Iran.
Carmen SergiouErasmus University Rotterdam, The Netherlands.
Alireza ShahbabaieLeibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.
Christine ShefferRoswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Primavera A SpagnoloNational Institutes of Health, USA.
Vaughn R SteeleNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Ti-Fei YuanShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, China.
Josanne D M van DongenErasmus University Rotterdam, The Netherlands.
Vincent Van WaesLaboratoire de Neurosciences Intégratives et Cliniques EA481, Université Bourgogne Franche-Comté, Besançon, France.
Ganesan VenkatasubramanianNational Institute of Mental Health and Neurosciences, India.
Antonio Verdejo-GarcíaTurner Institute for Brain and Mental Health, Monash University, Australia.
Ilse VerveerErasmus University Rotterdam, The Netherlands.
Justine W WelshDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Michael J WesleyUniversity of Kentucky College of Medicine, USA.
Katie WitkiewitzThe Mind Research Network, USA.
Fatemeh YavariLeibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.
Mohammad-Reza ZarrindastDepartment of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Laurie ZawertailoUniversity of Toronto, Canada; Centre for Addiction and Mental Health (CAMH), Canada.
Xiaochu ZhangUniversity of Science and Technology of China, China.
Yoon-Hee ChaLaureate Institute for Brain Research, USA.
Tony P GeorgeUniversity of Toronto, Canada; Centre for Addiction and Mental Health (CAMH), Canada.
Flavio FrohlichUniversity of North Carolina at Chapel Hill, USA.
Anna E GoudriaanDepartment of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Arkin, Department of Research and Quality of Care, Amsterdam, The Netherlands.
Shirley FecteauLaval University, Canada.
Stacey B DaughtersUniversity of North Carolina at Chapel Hill, USA.
Elliot A SteinNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Felipe FregniSpaulding Rehabilitation Hospital, Harvard Medical School, USA.
Michael A NitscheLeibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany; University Medical Hospital Bergmannsheil, Dept. Neurology, Bochum, Germany.
Abraham ZangenBen Gurion University of the Negev, Israel.
Marom BiksonThe City College of New York, USA.
Colleen A HanlonMedical University of South Carolina (MUSC), USA.
National Institutes of Health · USMind Research Network · USRoswell Park Comprehensive Cancer Center · USTU Dortmund University · DEUniversity of Kentucky · USUniversity of North Carolina at Chapel Hill · USCentre for Addiction and Mental Health · CAFirst Pavlov State Medical University of St. Petersburg · RUGhent University Hospital · BELaureate Institute for Brain Research · USMedical University of South Carolina · USUniversity of Chieti-Pescara · ITUniversity of Science and Technology of China · CNAgostino Gemelli University Polyclinic · ITBen-Gurion University of the Negev · ILCity College of New York · USEmory University · USHarvard University · USInstitute for Cognitive Science Studies · IRNantes Université · FR

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Patrick J. Mulholland · 1996 to 2026
$46.8M
Brain Imaging of Human Drug AbuseZIADA000470 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI STEIN, ELLIOT A · 2009 to 2021
$15.8M
Technology Enhanced Behavioral Activation Treatment for Substance UseR01DA026424 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAUGHTERS, STACEY B · 2010 to 2019
$4.4M
A Translational Determination of the Mechanisms of Maladaptive Choice in Opioid Use DisorderR01DA047368 · NIDA · UNIVERSITY OF KENTUCKY · PI BECKMANN, JOSHUA, LILE, JOSHUA ANTHONY · 2019 to 2023
$3.1M
A translational determination of the mechanisms of maladaptive choice in cocaine use disorderR01DA045023 · NIDA · UNIVERSITY OF KENTUCKY · PI BECKMANN, JOSHUA, LILE, JOSHUA ANTHONY · 2018 to 2022
$3.0M
A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use DisorderK23DA043628 · NIDA · STANFORD UNIVERSITY · PI SAHLEM, GREGORY · 2017 to 2022
$933k
Neural Mechanisms of Cannabinoid-Impaired Decision-Making in Emerging AdultsK01DA043652 · NIDA · UNIVERSITY OF KENTUCKY · PI WESLEY, MICHAEL J · 2018 to 2022
$792k
NIAAA NIH HHS P50 AA010761NIDA NIH HHS K01 DA043652NIDA NIH HHS K23 DA043628NIDA NIH HHS R01 DA026424NIDA NIH HHS R01 DA045023NIDA NIH HHS R01 DA047368
6 · The paper itself

Abstract

There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data - emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.

Indexed as

Addiction MedicineHumansOutcome Assessment, Health CareSubstance-Related DisordersTranscranial Direct Current StimulationTranscranial Magnetic StimulationAddictionNIBSNon-invasive brain stimulationPsychiatryrTMSSubstance use disordertDCStESTranscranial electrical stimulationTranscranial magnetic stimulation

Identifiers

PMID31271802
PMCPMC7293143
OpenAlexW2955210960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.