ReviewNeuron2019
Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies.
Review in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Consensus Statements on the Definition, Classification, and Diagnostic Tests for Tinnitus: A Delphi Study Conducted by the Korean Tinnitus Study Group.Journal of Korean medical science · 2024Pooled it
- Reversing Synchronized Brain Circuits Using Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts: A Randomized Clinical Trial.JAMA network open · 2023Trial
- The effects of photobiomodulation therapy in individuals with tinnitus and without hearing loss.Lasers in medical science · 2022Trial
- Inflammatory Signatures of Tinnitus in Patients and Mice.Neuroscience bulletin · 2026Article
- Mandibular Movement During Swallowing in Patients with Tinnitus: An Instrumented Case-Control Study.Audiology research · 2026Article
- Mid-infrared photons relieve tinnitus-like behavior of mice by regulating HCN2 ion channels in the medial geniculate body.Annals of medicine · 2025Article
- Review
- Effects of Noise Stress on Neuronal Activation in Rat Auditory Pathway-Related Brain Regions.Diagnostics (Basel, Switzerland) · 2025Article
- Effect of Topical Intra-Auricular Lidocaine on Tinnitus: A Randomized Double-Blind Placebo-Controlled Study.International archives of otorhinolaryngology · 2025Article
- Nrf2 deficiency enhances oxidative stress and promotes susceptibility to tinnitus in mice.Scientific reports · 2025Article
- Enhanced classification of tinnitus patients using EEG microstates and deep learning techniques.Scientific reports · 2025Article
- Involvement of BK Channels and Ryanodine Receptors in Salicylate-induced Tinnitus.Molecular neurobiology · 2025Article
- Reversing Cochlear Nucleus Maladaptive Plasticity via Customized Extracochlear Stimulation: A New Approach for Tinnitus Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Research trends and hotspots of cognitive behavioral therapy for tinnitus: a bibliometric analysis.Frontiers in neuroscience · 2025Article
- Astrocytes and Tinnitus.Brain sciences · 2024Review
- Lack of Amino Acid Alterations Within the Cochlear Nucleus and the Auditory Cortex in Acoustic Trauma-Induced Tinnitus Rats Using In Vivo Microdialysis.Audiology research · 2024Article
- Optimization of the Operant Silent Gap-in-Noise Detection Paradigm in Humans.Journal of integrative neuroscience · 2024Observational
- Candidate Key Proteins in Tinnitus-A Bioinformatic Study of Synaptic Transmission in the Cochlear Nucleus.Biomedicines · 2024Article
- Cortical determinants of loudness perception and auditory hypersensitivity.bioRxiv : the preprint server for biology · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tinnitus, sound perception in the absence of physical stimuli, occurs in 15% of the population and is the top-reported disability for soldiers after combat. Noise overexposure is a major factor associated with tinnitus but does not always lead to tinnitus. Furthermore, people with normal audiograms can get tinnitus. In animal models, equivalent cochlear damage occurs in animals with and without behavioral evidence of tinnitus. But cochlear-nerve-recipient neurons in the brainstem demonstrate distinct, synchronized spontaneous firing patterns only in animals that develop tinnitus, driving activity in central brain regions and ultimately giving rise to phantom perception. Examining tinnitus-specific changes in single-cell populations enables us to begin to distinguish neural changes due to tinnitus from those that are due to hearing loss.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.