Evidence map›Paper›PMID 31271749›Full record

ArticleCell stem cell2019

Is Alzheimer's Disease a Neurogenesis Disorder?

Se Hoon Choi, Rudolph E Tanzi

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Increasing adult-born neurons protects mice from epilepsy.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Article
  11. Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Se Hoon ChoiGenetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Rudolph E TanziGenetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: tanzi@helix.mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The existence of adult hippocampal neurogenesis (AHN) in humans has been controversial. However, recent reports have detected AHN in aged adults and patients with mild cognitive impairment and Alzheimer's disease (AD), suggesting that therapies aimed at promoting AHN may be useful for the prevention and treatment of AD.

Indexed as

Alzheimer DiseaseAdultHealthy VolunteersHippocampusHumansMiddle AgedNeurogenesis

Identifiers

PMID31271749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.