Evidence map›Paper›PMID 31271746›Full record

ArticleCell stem cell2019

Putting Stem Cells on a Low-Fat Diet Switches Their Pluripotent State.

Zongmin Jiang, Lu Guang, Lei Li, Ng Shyh-Chang

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. The Metabaging Cycle.Cell proliferation · 2022
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Zongmin JiangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; University of Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China.
Lu GuangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; University of Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China.
Lei LiState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; University of Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China.
Ng Shyh-ChangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; University of Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China. Electronic address: huangsq@ioz.ac.cn.

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Previous work demonstrating the importance of stem cell metabolism in regulating development ignited a debate on how intrinsic versus extrinsic conditions influence metabolic programming of epigenetics. In this issue of Cell Stem Cell, Cornacchia et al. show that exogenous lipids regulate an acetyl-CoA-dependent switch to influence the intrinsic pluripotent state of hPSCs.

Indexed as

Embryonic Stem CellsPluripotent Stem CellsCell DifferentiationDiet, Fat-RestrictedHumansLipidsLipids

Identifiers

PMID31271746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.