ArticleBrain and behavior2019
Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Neuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [European journal of nuclear medicine and molecular imaging · 2026Article
- Deprivation-Induced Plasticity in the Early Central Circuits of the Rodent Visual, Auditory, and Olfactory Systems.eNeuro · 2024Review
- Does age protect against loss of tonotopy after acute deafness in adulthood?Frontiers in cellular neuroscience · 2024Article
- Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus.Frontiers in aging neuroscience · 2023Article
- Inferior collicular cells that project to the auditory thalamus are increasingly surrounded by perineuronal nets with age.Neurobiology of aging · 2021Article
- The Density of Perineuronal Nets Increases With Age in the Inferior Colliculus in the Fischer Brown Norway Rat.Frontiers in aging neuroscience · 2020Article
- Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem.Brain and behavior · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionCochlear ablation causing sensory deafferentation (SD) of the cochlear nucleus triggers complex re-arrangements in the cellular and molecular communication networks of the adult mammalian central auditory system. Participation of the extracellular matrix (ECM) in these processes is not well understood.
methodsWe investigated consequences of unilateral SD for the expression and distribution of the chondroitin sulfate proteoglycans, neurocan (Ncan) and aggrecan (Agg), alongside various plasticity markers in the auditory brainstem of the adult rat using immunohistochemical techniques.
resultsIn the deafferented ventral cochlear nucleus (VCN), Ncan expression increased massively within 3 postoperative days (POD), but rapidly decreased thereafter. Agg showed a similar but less pronounced progression. Decrease in Ncan was spatially and temporally related to the re-innervation of VCN documented by the emergence of growth-associated protein Gap43 contained in nerve fibers and presynaptic boutons. Concurrently, astrocytes grew and expressed matrix metalloproteinase-2 (MMP2), an enzyme known to emerge only under re-innervation of VCN. MMP2 is capable of cleaving both Ncan and Agg when released. A transient modulation of the ECM in the central inferior colliculus on the side opposite to SD occurred by POD1. Modulations of glutamatergic synapses and Gap43 expression were detected, reflecting state changes of the surrounding tissue induced by transsynaptic effects of SD.
conclusionsThe ECM variously participates in adaptive responses to sudden deafness by SD on several levels along the central auditory pathway, with a striking spatial and temporal relationship of Ncan modulation to astrocytic activation and to synaptogenesis.
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