ArticleGenesis (New York, N.Y. : 2000)2019
Generation and characterization of DSPP-Cerulean/DMP1-Cherry reporter mice.
Article in Genesis (New York, N.Y. : 2000), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Spatial Transcriptomics-Inspired Targeted Hydrogel for Dental Pulp Therapy via Strengthen Macrophage Communication.Advanced healthcare materials · 2026Article
- Isolated dentinogenesis imperfecta: Novel DSPP variants and insights on genetic counselling.Clinical oral investigations · 2024Article
- Myeloid differentiation factor 2 inhibitors exert protective effects on lipopolysaccharides-treated human dental pulp cells via suppression of toll-like receptor 4-mediated signaling.Journal of dental sciences · 2024Article
- Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue.Scientific reports · 2023Article
- Review
- The Development of Dentin Microstructure Is Controlled by the Type of Adjacent Epithelium.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation.International journal of oral science · 2022Article
- Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.Frontiers in physiology · 2022Article
- Wnt/β-Catenin Signaling Promotes the Formation of Preodontoblasts In Vitro.Journal of dental research · 2021Article
- Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.Nature communications · 2020Article
- Comparison of osteogenic and dentinogenic potentials of mice incisor and molar pulps in vitro.Archives of oral biology · 2020Article
- Expression of BSP-GFPtpz Transgene during Osteogenesis and Reparative Dentinogenesis.Journal of dental research · 2020Article
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
Abstract
To gain a better understanding of the progression of progenitor cells in the odontoblast lineage, we have examined and characterized the expression of a series of GFP reporters during odontoblast differentiation. However, previously reported GFP reporters (pOBCol2.3-GFP, pOBCol3.6-GFP, and DMP1-GFP), similar to the endogenous proteins, are also expressed by bone-forming cells, which made it difficult to delineate the two cell types in various in vivo and in vitro studies. To overcome these difficulties we generated DSPP-Cerulean/DMP1-Cherry transgenic mice using a bacterial recombination strategy with the mouse BAC clone RP24-258g7. We have analyzed the temporal and spatial expression of both transgenes in tooth and bone in vivo and in vitro. This transgenic animal enabled us to visualize the interactions between odontoblasts and surrounding tissues including dental pulp, ameloblasts and cementoblasts. Our studies showed that DMP1-Cherry, similar to Dmp1, was expressed in functional and fully differentiated odontoblasts as well as osteoblasts, osteocytes and cementoblasts. Expression of DSPP-Cerulean transgene was limited to functional and fully differentiated odontoblasts and correlated with the expression of Dspp. This transgenic animal can help in the identification and isolation of odontoblasts at later stages of differentiation and help in better understanding of developmental disorders in dentin and odontoblasts.
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