Evidence map›Paper›PMID 31271054›Full record

ArticleCell transplantation

A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment.

Konstantinos Pantos, Mara Simopoulou, Agni Pantou, Anna Rapani, Petroula Tsioulou, Nikolaos Nitsos, Stephen Syrkos, Athanasios Pappas, Michael Koutsilieris, Konstantinos Sfakianoudis

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 7 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 7 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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  12. Clinical practice guidelines for the management of differences of sex development in Japan.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Konstantinos PantosCentre for Human Reproduction, Genesis Athens Clinic, Greece.
Mara SimopoulouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Greece.
Agni PantouCentre for Human Reproduction, Genesis Athens Clinic, Greece.ORCID 0000-0003-3224-5646
Anna RapaniDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Greece.
Petroula TsioulouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Greece.
Nikolaos NitsosMicrobiology-Biochemical Department, Genesis Athens Clinic, Greece.
Stephen SyrkosCentre for Human Reproduction, Genesis Athens Clinic, Greece.
Athanasios PappasCentre for Human Reproduction, Genesis Athens Clinic, Greece.
Michael KoutsilierisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Greece.
Konstantinos SfakianoudisCentre for Human Reproduction, Genesis Athens Clinic, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and the anti-aging process, employing angiogenesis regeneration due to the multiple growth factors and cytokines involved. Numerous reports have shown promising results with the use of PRP in ovarian treatment, regarding ovarian regeneration and reactivation of folliculogenesis. This case series reports on two women with premature ovarian failure (POF) aged 40 and 27 years, respectively, and one menopausal woman aged 46 years. All patients presented with lack of menstrual cycle for over a year. The women reported previous failed in vitro fertilization (IVF) attempts, and, after rejecting the option of oocyte donation, they opted for the approach of autologous ovarian PRP treatment. Following PRP treatment, the three patients were invited to conceive naturally. The primary outcome was the restoration of menstruation following autologous ovarian PRP treatment, as well as an improvement in hormonal profile, a decrease in follicle-stimulating hormone (FSH) levels, and a concurrent increase in anti-Müllerian hormone (AMH) levels. Further to that, our patients achieved pregnancy through natural conception within 2-6 months following PRP treatment, resulting in currently ongoing complication-free clinical pregnancies - a first report in the literature for menopausal and POF patients. Implementation of PRP should be further investigated through randomized controlled trials (RCTs), as it may hold the key to successful treatment for a certain cohort of patients exploring reproductive treatment options following menopause.

Indexed as

Fertilization in VitroMenopause, PrematurePlatelet-Rich PlasmaAdultFemaleHumansMiddle AgedPregnancymenopauseongoing pregnanciesplatelet-rich plasmapremature menopause

Identifiers

PMID31271054
PMCPMC6767896
OpenAlexW2953629593

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.